Propionate Affects Insulin Signaling and Progesterone Profiles in Dairy Heifers

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dc.contributor.authorBedford, Andreaen
dc.contributor.authorBeckett, Lindaen
dc.contributor.authorHardin, K.en
dc.contributor.authorDias, Nicholas W.en
dc.contributor.authorDavis, Ty C.en
dc.contributor.authorMercadante, Vitor R. G.en
dc.contributor.authorEaly, Alan D.en
dc.contributor.authorWhite, Robin R.en
dc.date.accessioned2021-10-19T12:15:06Zen
dc.date.available2021-10-19T12:15:06Zen
dc.date.issued2018-12-04en
dc.date.updated2021-10-19T12:15:03Zen
dc.description.abstractEmerging data highlighting gut microbiome influences on health support evaluation of how microbial fermentation end-products influence postabsorptive systems. This study aimed to investigate the effect of increased propionate status on progesterone profiles and insulin sensitivity in dairy heifers. Eleven Holstein heifers, synchronized in estrus, were assigned to one of two continuous, 5-day IV treatments: sodium propionate (PRO; n = 5) or saline (CON; n = 6). These infusions culminated in a hyperglycemic clamp with daily blood samples for an additional 7 days. Plasma propionate concentrations increased over the first 9 h in PRO heifers, then decreased until day 3 when they matched CON heifers. Maximum plasma progesterone concentrations tended to be greater in PRO heifers than CON heifers (4.19 vs 3.73 ng/mL; P = 0.087). Plateau insulin concentrations in CON animals were significantly greater than those in PRO animals (249.4 ± 25.1 vs 123.9 ± 35.8; P = 0.008) with a trend for an increased insulin sensitivity index in PRO heifers compared to CON heifers (P = 0.06). These changes in plasma propionate clearance leading to increased progesterone response and changes in insulin sensitivity suggest a role for SCFA metabolism in reproductive hormone regulation.en
dc.description.versionPublished versionen
dc.format.extent10 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 17629 (Article number)en
dc.identifier.doihttps://doi.org/10.1038/s41598-018-35977-1en
dc.identifier.eissn2045-2322en
dc.identifier.issn2045-2322en
dc.identifier.issue1en
dc.identifier.orcidWhite, Robin [0000-0001-5713-012X]en
dc.identifier.orcidMercadante, Vitor [0000-0002-1229-2325]en
dc.identifier.orcidEaly, Alan [0000-0002-8507-6578]en
dc.identifier.other10.1038/s41598-018-35977-1 (PII)en
dc.identifier.pmid30514961en
dc.identifier.urihttp://hdl.handle.net/10919/105412en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000452084600037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectchain fatty-acidsen
dc.subjectplasma-insulinen
dc.subjectenergy-balanceen
dc.subjectchromium propionateen
dc.subjectglucagon-responsesen
dc.subjectglucose-toleranceen
dc.subjectadipose-tissueen
dc.subjectpregnancy rateen
dc.subjectblood-flowen
dc.subjectmetabolismen
dc.subject.meshPlasmaen
dc.subject.meshAnimalsen
dc.subject.meshCattleen
dc.subject.meshPropionatesen
dc.subject.meshProgesteroneen
dc.subject.meshInsulinen
dc.subject.meshInfusions, Intravenousen
dc.subject.meshSaline Solutionen
dc.titlePropionate Affects Insulin Signaling and Progesterone Profiles in Dairy Heifersen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2018-11-12en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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