New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis
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Date
2016-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
A new artificial fluoro-cofactor was developed for the replacement of natural cofactors NAD(P), exhibiting a high hydride transfer ability. More importantly, we established a new and fast screening method for the evaluation of the properties of artificial cofactors based on the fluorescence assay and visible color change.
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Keywords
Chemistry, Multidisciplinary, Chemistry, BIOMIMETIC ASYMMETRIC HYDROGENATION, 1,4-NADH DERIVATIVES, BIOORGANOMETALLIC CHEMISTRY, REGIOSELECTIVE REDUCTION, MEDICINAL CHEMISTRY, MECHANISTIC ASPECTS, NAD(P)H OXIDASE, NAD(+) MODELS, REGENERATION, NICOTINAMIDE