Granular retrosplenial cortex layer 2/3 generates high-frequency oscillations dynamically coupled with hippocampal rhythms across brain states

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dc.contributor.authorArndt, Kaiser C.en
dc.contributor.authorGilbert, Earl T.en
dc.contributor.authorKlaver, Lianne M.F.en
dc.contributor.authorKim, Jongwoonen
dc.contributor.authorBuhler, Chelsea M.en
dc.contributor.authorBasso, Julia C.en
dc.contributor.authorMcKenzie, Samen
dc.contributor.authorEnglish, Daniel Fineen
dc.date.accessioned2024-06-07T17:32:12Zen
dc.date.available2024-06-07T17:32:12Zen
dc.date.issued2024-03-26en
dc.description.abstractThe granular retrosplenial cortex (gRSC) exhibits high-frequency oscillations (HFOs; ~150 Hz), which can be driven by a hippocampus-subiculum pathway. How the cellular-synaptic and laminar organization of gRSC facilitates HFOs is unknown. Here, we probe gRSC HFO generation and coupling with hippocampal rhythms using focal optogenetics and silicon-probe recordings in behaving mice. ChR2-mediated excitation of CaMKII-expressing cells in L2/3 or L5 induces HFOs, but spontaneous HFOs are found only in L2/3, where HFO power is highest. HFOs couple to CA1 sharp wave-ripples (SPW-Rs) during rest and the descending phase of theta. gRSC HFO current sources and sinks are the same for events during both SPW-Rs and theta oscillations. Independent component analysis shows that high gamma (50–100 Hz) in CA1 stratum lacunosum moleculare is comodulated with HFO power. HFOs may thus facilitate interregional communication of a multisynaptic loop between the gRSC, hippocampus, and medial entorhinal cortex during distinct brain and behavioral states.en
dc.description.sponsorshipD.F.E. is supported by grants from the Simons Foundation and the Whitehall Foundation. S.M. is supported by the National Institute of Mental Health (NIMH) grant no. R00MH11842. K.C.A. is supported by the Virginia Tech School of Neuroscience and the Virginia Tech Molecular and Cellular Biology program.en
dc.format.extent16 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2024.113910en
dc.identifier.urihttps://hdl.handle.net/10919/119344en
dc.identifier.volume43en
dc.language.isoenen
dc.publisherCellPressen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleGranular retrosplenial cortex layer 2/3 generates high-frequency oscillations dynamically coupled with hippocampal rhythms across brain statesen
dc.title.serialCell Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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