VTechWorks staff will be away for the Thanksgiving holiday beginning at noon on Wednesday, November 27, through Friday, November 29. We will resume normal operations on Monday, December 2. Thank you for your patience.
 

The effects of orally administered trazodone on ambulation and recumbency in healthy horses

Simple item page
dc.contributor.authorHobbs, Kallieen
dc.contributor.authorLuethy, Danielaen
dc.contributor.authorDavis, Jennifer L.en
dc.contributor.authorMallicote, Marthaen
dc.contributor.authorTorcivia, Catherineen
dc.contributor.authorKulp, Jeaneenen
dc.contributor.authorStefanovski, Darkoen
dc.contributor.authorFutterman, Catherineen
dc.contributor.authorCooper, Freyaen
dc.contributor.authorVan Eps, Andrewen
dc.date.accessioned2024-01-19T13:39:12Zen
dc.date.available2024-01-19T13:39:12Zen
dc.date.issued2023-09en
dc.description.abstractBackground: Trazodone, a serotonin receptor antagonist and reuptake inhibitor, might be a useful adjunctive treatment in the initial management of horses with acute laminitis if it minimizes ambulation or encourages recumbency. Objectives: (1) Evaluate the effects of PO trazodone on ambulatory activity and recumbency in healthy horses; and (2) assess the pharmacokinetics of multiple PO doses of trazodone. Animals/Methods: In a randomized cross-over design, 8 healthy horses received placebo or trazodone at 2 doses (2.5 and 7.5 mg/kg) PO q12h for 48 hours with a 14-day washout period between treatments. Forelimb step frequency was measured using a hoof-mounted accelerometer and continuous video monitoring was used to detect recumbency. Groups were compared using repeated measures analysis of variance with Tukey's post hoc test. Trazodone and m-chlorophenylpiperazine (m-CPP) plasma concentrations were determined by ultra-high performance liquid chromatography-tandem mass spectrometry and pharmacokinetics were analyzed using noncompartmental methods. Results: Step frequency was lower in horses receiving 7.5 mg/kg trazodone than in the control group (mean step reduction: 44% ± 11%). Steps-area under the curve were significantly lower in the 7.5 mg/kg group (mean ± SD: 3375 ± 525 steps × hour) as compared to the 2.5 mg/kg group (mean ± SD: 5901 ± 2232; P =.02) and compared to control (mean ± SD: 6590 ± 1241; P =.001). No difference was found in the number of recumbent episodes (P =.92) or total duration of recumbency (P =.9). Trazodone and m-CPP achieved steady-state concentrations, with an accumulation ratio of 1.45 ± 0.2. Conclusions and Clinical Importance: Although it did not affect recumbency, trazodone at 7.5 mg/kg q12h decreased step frequency by approximately 44%.en
dc.description.versionPublished versionen
dc.format.extentPages 1899-1906en
dc.format.extent8 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.16821en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue5en
dc.identifier.orcidDavis, Jennifer [0000-0002-7930-4589]en
dc.identifier.pmid37489582en
dc.identifier.urihttps://hdl.handle.net/10919/117406en
dc.identifier.volume37en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/37489582en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectlaminitisen
dc.subjectorthopedicen
dc.subjectpharmacokineticsen
dc.subjectsedationen
dc.titleThe effects of orally administered trazodone on ambulation and recumbency in healthy horsesen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2023-07-07en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hobbs_Effects.pdf
Size:
950.37 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Plain Text
Description:
Download

Collections

All Faculty Deposits
Scholarly Works, Biomedical Sciences and Pathobiology