Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia

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dc.contributor.authorSullivan-Toole, Hollyen
dc.contributor.authorFeng, Shengchuangen
dc.contributor.authorCarlton, Corinne N.en
dc.contributor.authorGhane, Merageen
dc.contributor.authorOlino, Thomas M.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.authorRichey, John A.en
dc.date.accessioned2023-04-18T15:06:13Zen
dc.date.available2023-04-18T15:06:13Zen
dc.date.issued2022-11en
dc.description.abstractAffective immunology of the skin is a growing area; however, established protocols for measuring individual differences in cutaneous inflammation are lacking. To address this, we present a preliminary validation of Precision Implementation of Minimal Erythema Dose (PI-MED) testing as a method for measuring cutaneous inflammation. PI-MED is a recently adapted protocol, optimized for reproducibility and individual differences research, that uses ultraviolet (UV) light to evoke cutaneous erythema, or inflammatory skin reddening. PI-MED's novel UV dosage schedule produces standardized erythema responses across different skin pigmentation types and shows strong internal consistency within person and good test-retest reliability across 8-10 weeks. In line with predictions, increased PI-MED erythema was associated with heightened anhedonia, across several measures, beyond influences of non-affective covariates. While future work should further refine the dosage schedule for the lightest and darkest skin types, overall, evidence supports PI-MED as a protocol for inducing and measuring individual differences in cutaneous inflammation. Further, PI-MED-induced erythema can expand psychoneuroimmunology research by offering a complementary assessment for general inflammatory tone. This work adds to a growing body of evidence demonstrating a distinct relationship between inflammation and anhedonia.en
dc.description.notesThe authors gratefully acknowledge the primary source of funding for this work, the Virginia Tech College of Science 'Dean's Discovery Fund'.en
dc.description.sponsorshipVirginia Tech College of Science 'Dean's Discovery Fund'en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-022-24598-4en
dc.identifier.issue1en
dc.identifier.other20237en
dc.identifier.pmid36424456en
dc.identifier.urihttp://hdl.handle.net/10919/114540en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherNature Portfolioen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectC-reactive proteinen
dc.subjectpsychological stressen
dc.subjectpositive emotionsen
dc.subjectsocial experienceen
dc.subjecthuman skinen
dc.subjectalphaen
dc.subjectsensitivityen
dc.subjectdepressionen
dc.subjectneuroendocrineen
dc.subjectinterleukin-6en
dc.titleValidation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedoniaen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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