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Epidermal growth factor receptor in equine gastric stratified squamous mucosa: effect of progressive ulceration on receptor density

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dc.contributor.authorJeffrey, Stuart C.en
dc.contributor.committeememberMurray, Michael J.en
dc.contributor.committeememberPfeiffer, Carl J.en
dc.contributor.committeememberRobertson, John L.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T21:46:04Zen
dc.date.adate2008-09-18en
dc.date.available2014-03-14T21:46:04Zen
dc.date.issued1996-02-05en
dc.date.rdate2008-09-18en
dc.date.sdate2008-09-18en
dc.description.abstractThe objective of the study reported here was to document the distribution of epidermal growth factor receptor (EGFr) and quantitate receptor density in normal as well as ulcerated equine gastric squamous mucosa. Fifteen horses with endoscopically normal stomachs were divided into three equal groups. Group 1 was a normal control. A protocol that alternated 24 hour periods of free-choice hay with 24 hours of feed deprivation was utilized to induce squamous mucosal gastric ulceration in Group 2 (48 hours total off-feed) and Group 3 (96 hours total off-feed). Gastric tissue was collected from 3 stomach locations at post-mortem examination and an avidin-biotin immunoperoxidase technique was developed to stain the formalin-fixed tissue for EGFr. A computerized image analysis system was used to measure EGFr area and mean intensity values at four sites within the epithelium from the basal cell layers to the lumen in the ulcer/erosion margin, erosion bed, and 10-14 mm distant from the lesion.en
dc.description.degreeMaster of Scienceen
dc.format.extentvi, 123 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-09182008-063547en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-09182008-063547/en
dc.identifier.urihttp://hdl.handle.net/10919/44831en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1996.J444.pdfen
dc.relation.isformatofOCLC# 36436374en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectgastric ulcersen
dc.subjectepidermal growth factor receptoren
dc.subjectequineen
dc.subject.lccLD5655.V855 1996.J444en
dc.titleEpidermal growth factor receptor in equine gastric stratified squamous mucosa: effect of progressive ulceration on receptor densityen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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