Phylogenetic Analysis of the SNORD116 Locus
| dc.contributor.author | Kocher, Matthew A. | en |
| dc.contributor.author | Good, Deborah J. | en |
| dc.contributor.department | Human Nutrition, Foods, and Exercise | en |
| dc.date.accessioned | 2017-12-22T13:39:48Z | en |
| dc.date.available | 2017-12-22T13:39:48Z | en |
| dc.date.issued | 2017-11-30 | en |
| dc.date.updated | 2017-12-22T12:21:50Z | en |
| dc.description.abstract | The <i>SNORD116</i> small nucleolar RNA locus (<i>SNORD116@</i>) is contained within the long noncoding RNA host gene <i>SNHG14</i> on human chromosome 15q11-q13. The <i>SNORD116</i> locus is a cluster of 28 or more small nucleolar (sno) RNAs; C/D box (SNORDs). Individual RNAs within the cluster are tandem, highly similar sequences, referred to as <i>SNORD116-1</i>, <i>SNORD116-2</i>, etc., with the entire set referred to as <i>SNORD116</i>@. There are also related <i>SNORD116</i> loci on other chromosomes, and these additional loci are conserved among primates. Inherited chromosomal 15q11-q13 deletions, encompassing the <i>SNORD116</i>@ locus, are causative for the paternally-inherited/maternally-imprinted genetic condition, Prader–Willi syndrome (PWS). Using in silico tools, along with molecular-based and sequenced-based confirmation, phylogenetic analysis of the <i>SNORD116</i>@ locus was performed. The consensus sequence for the SNORD116@ snoRNAs from various species was determined both for all the <i>SNORD116</i> snoRNAs, as well as those grouped using sequence and location according to a human grouping convention. The implications of these findings are put in perspective for studying <i>SNORD116</i> in patients with inherited Prader–Willi syndrome, as well as model organisms. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Kocher, M.A.; Good, D.J. Phylogenetic Analysis of the SNORD116 Locus. Genes 2017, 8, 358. | en |
| dc.identifier.doi | https://doi.org/10.3390/genes8120358 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/81393 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Prader–Willi Syndrome | en |
| dc.subject | snoRNA | en |
| dc.subject | phylogenetic analysis | en |
| dc.subject | imprinting | en |
| dc.title | Phylogenetic Analysis of the SNORD116 Locus | en |
| dc.title.serial | Genes | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |