The Asymmetric Synthesis Of The C1'-C10' Portion of Pamamycin-621A

This thesis describes the synthesis of the C1'-C10' portion 72 of the pamamycin-621A using a cuprate conjugate addition to join enone fragment 52 and organostannane fragment 64a. Fragments 52 and 64a were both synthesized from (S)-methylketene dimer 51.