Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine

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dc.contributor.authorLin, Zhoumengen
dc.contributor.authorLi, Miaoen
dc.contributor.authorWang, Yu-Shinen
dc.contributor.authorTell, Lisa A.en
dc.contributor.authorBaynes, Ronald E.en
dc.contributor.authorDavis, Jennifer L.en
dc.contributor.authorVickroy, Thomas W.en
dc.contributor.authorRiviere, Jim E.en
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-09-07T14:46:34Zen
dc.date.available2021-09-07T14:46:34Zen
dc.date.issued2020-04-08en
dc.date.updated2021-09-07T14:46:30Zen
dc.description.abstractPhysiologically based pharmacokinetic (PBPK) models for chemicals in food animals are a useful tool in estimating chemical tissue residues and withdrawal intervals. Physiological parameters such as organ weights and blood flows are an important component of a PBPK model. The objective of this study was to compile PBPK-related physiological parameter data in food animals, including cattle and swine. Comprehensive literature searches were performed in PubMed, Google Scholar, ScienceDirect, and ProQuest. Relevant literature was reviewed and tables of relevant parameters such as relative organ weights (% of body weight) and relative blood flows (% of cardiac output) were compiled for different production classes of cattle and swine. The mean and standard deviation of each parameter were calculated to characterize their variability and uncertainty and to allow investigators to conduct population PBPK analysis via Monte Carlo simulations. Regression equations using weight or age were created for parameters having sufficient data. These compiled data provide a comprehensive physiological parameter database for developing PBPK models of chemicals in cattle and swine to support animal-derived food safety assessment. This work also provides a basis to compile data in other food animal species, including goats, sheep, chickens, and turkeys.en
dc.description.versionPublished versionen
dc.format.extentPages 385-420en
dc.format.extent36 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvp.12861en
dc.identifier.eissn1365-2885en
dc.identifier.issn0140-7783en
dc.identifier.issue5en
dc.identifier.orcidDavis, Jennifer [0000-0002-7930-4589]en
dc.identifier.pmid32270548en
dc.identifier.urihttp://hdl.handle.net/10919/104941en
dc.identifier.volume43en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000559944700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectPharmacology & Pharmacyen
dc.subjectVeterinary Sciencesen
dc.subjectblood flowen
dc.subjectfood safetyen
dc.subjectorgan weighten
dc.subjectphysiologically based pharmacokinetic modelen
dc.subjectwithdrawal intervalen
dc.subjectVISCERAL ORGAN MASSen
dc.subjectFASTING HEAT-PRODUCTIONen
dc.subjectPORTAL BLOOD-FLOWen
dc.subjectREPLACING SOYBEAN PROTEINen
dc.subjectCORONARY VASCULAR RESERVEen
dc.subjectSMALL-INTESTINAL GROWTHen
dc.subjectGROWING BEEF HEIFERSen
dc.subjectTO-CONCENTRATE RATIOen
dc.subjectLANDRACE X YORKSHIREen
dc.subjectBODY-FAT COMPOSITIONen
dc.subject0707 Veterinary Sciencesen
dc.subject.meshAnimalsen
dc.subject.meshCattleen
dc.subject.meshSwineen
dc.subject.meshPharmaceutical Preparationsen
dc.subject.meshDrug Residuesen
dc.subject.meshPharmacokineticsen
dc.subject.meshModels, Biologicalen
dc.titlePhysiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swineen
dc.title.serialJournal of Veterinary Pharmacology and Therapeuticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2020-03-04en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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