Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound
| dc.contributor.author | Sandal, Indra | en |
| dc.contributor.author | Bhattacharya, Amita | en |
| dc.contributor.author | Saini, Uksha | en |
| dc.contributor.author | Kaur, Devinder | en |
| dc.contributor.author | Sharma, Shveta | en |
| dc.contributor.author | Gulati, Ashu | en |
| dc.contributor.author | Kumar, Jonnala K. | en |
| dc.contributor.author | Kumar, Neeraj | en |
| dc.contributor.author | Dayma, Jyotsna | en |
| dc.contributor.author | Das, Pralay | en |
| dc.contributor.author | Singh, Bikram | en |
| dc.contributor.author | Ahuja, Paramvir S. | en |
| dc.date.accessioned | 2012-08-24T11:05:07Z | en |
| dc.date.available | 2012-08-24T11:05:07Z | en |
| dc.date.issued | 2011-05-31 | en |
| dc.date.updated | 2012-08-24T11:05:07Z | en |
| dc.description.abstract | Background Accidental autoclaving of L-glutamine was found to facilitate the Agrobacterium infection of a non host plant like tea in an earlier study. In the present communication, we elucidate the structural changes in L-glutamine due to autoclaving and also confirm the role of heat transformed L-glutamine in Agrobacterium mediated genetic transformation of host/non host plants. Results When autoclaved at 121°C and 15 psi for 20 or 40 min, L-glutamine was structurally modified into 5-oxo proline and 3-amino glutarimide (α-amino glutarimide), respectively. Of the two autoclaved products, only α-amino glutarimide facilitated Agrobacterium infection of a number of resistant to susceptible plants. However, the compound did not have any vir gene inducing property. Conclusions We report a one pot autoclave process for the synthesis of 5-oxo proline and α-amino glutarimide from L-glutamine. Xenobiotic detoxifying property of α-amino glutarimide is also proposed. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | BMC Chemical Biology. 2011 May 31;11(1):1 | en |
| dc.identifier.doi | https://doi.org/10.1186/1472-6769-11-1 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/18806 | en |
| dc.language.iso | en | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.holder | Indra Sandal et al.; licensee BioMed Central Ltd. | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.title | Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound | en |
| dc.title.serial | BMC Chemical Biology | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |