The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus

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dc.contributor.authorRen, Jingjingen
dc.contributor.authorPanther, Eric J.en
dc.contributor.authorLiao, Xiaofengen
dc.contributor.authorGrammer, Amrie C.en
dc.contributor.authorLipsky, Peter E.en
dc.contributor.authorReilly, Christopher M.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentVirginia-Maryland College of Veterinary Medicineen
dc.date.accessioned2018-12-21T15:37:25Zen
dc.date.available2018-12-21T15:37:25Zen
dc.date.issued2018-12-12en
dc.date.updated2018-12-21T14:52:40Zen
dc.description.abstractSystemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease in which the body’s immune system mistakenly attacks healthy cells. Although the exact cause of SLE has not been identified, it is clear that both genetics and environmental factors trigger the disease. Identical twins have a 24% chance of getting lupus disease if the other one is affected. Internal factors such as female gender and sex hormones, the major histocompatibility complex (MHC) locus and other genetic polymorphisms have been shown to affect SLE, as well as external, environmental influences such as sunlight exposure, smoking, vitamin D deficiency, and certain infections. Several studies have reported and proposed multiple associations between the alteration of the epigenome and the pathogenesis of autoimmune disease. Epigenetic factors contributing to SLE include microRNAs, DNA methylation status, and the acetylation/deacetylation of histone proteins. Additionally, the acetylation of non-histone proteins can also influence cellular function. A better understanding of non-genomic factors that regulate SLE will provide insight into the mechanisms that initiate and facilitate disease and also contribute to the development of novel therapeutics that can specifically target pathogenic molecular pathways.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRen, J.; Panther, E.; Liao, X.; Grammer, A.C.; Lipsky, P.E.; Reilly, C.M. The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2018, 19, 4007.en
dc.identifier.doihttps://doi.org/10.3390/ijms19124007en
dc.identifier.urihttp://hdl.handle.net/10919/86498en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsystemic lupus erythematosusen
dc.subjectlupusen
dc.subjectmethylationen
dc.subjectacetylationen
dc.subjecthistone deacetylase inhibitionen
dc.titleThe Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosusen
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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