High-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor margin

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dc.contributor.authorLatouche, Eduardo L.en
dc.contributor.committeechairDavalos, Rafael V.en
dc.contributor.committeememberLesko, John J.en
dc.contributor.committeememberRossmeisl, John H.en
dc.contributor.committeememberVerbridge, Scotten
dc.contributor.departmentEngineering Science and Mechanicsen
dc.date.accessioned2017-12-12T07:00:17Zen
dc.date.available2017-12-12T07:00:17Zen
dc.date.issued2016-06-19en
dc.description.abstractIrreversible electroporation (IRE) is a non-thermal ablation technique that allows for eradication of unresectable tumors in a minimally invasive procedure. While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given that one of the hallmarks of cancer cell morphology is larger, more abundant nuclei, our team set out to explore the possibility of preferentially targeting this physical and geometrical characteristic.en
dc.description.degreeMaster of Scienceen
dc.format.mediumETDen
dc.identifier.othervt_gsexam:7929en
dc.identifier.urihttp://hdl.handle.net/10919/81131en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectIREen
dc.subject3D cell cultureen
dc.subjectfocal ablationen
dc.subjectFEAen
dc.subjecttreatment planningen
dc.subjectglioblastomaen
dc.titleHigh-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor marginen
dc.typeThesisen
thesis.degree.disciplineEngineering Mechanicsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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