Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case-Control Study

Simple item page
dc.contributor.authorSaeedirad, Zahraen
dc.contributor.authorAriyanfar, Shadien
dc.contributor.authorNoormohammadi, Morvariden
dc.contributor.authorGhorbani, Zeinaben
dc.contributor.authorNaser Moghadasi, Abdorrezaen
dc.contributor.authorShahemi, Saharen
dc.contributor.authorGhanaatgar, Miladen
dc.contributor.authorRezaeimanesh, Nasimen
dc.contributor.authorHekmatdoost, Azitaen
dc.contributor.authorGhaemi, Amiren
dc.contributor.authorRazeghi Jahromi, Soodehen
dc.date.accessioned2023-08-11T17:28:17Zen
dc.date.available2023-08-11T17:28:17Zen
dc.date.issued2023-07-26en
dc.date.updated2023-08-11T14:33:19Zen
dc.description.abstractThis study aimed to investigate the association between dietary acid load (DAL) and multiple sclerosis (MS), through the potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. In a hospital-based case&ndash;control study of 109 patients with MS and 130 healthy individuals, a validated 168-item semi-quantitative food frequency questionnaire and a logistic regression model were used to evaluate the association between the DAL and MS. After adjusting for age (years), gender (male/female), body mass index (Kg/m<sup>2</sup>), and total calories (Kcal), the MS odds were 92% lower for those in the highest tertile of total plant-based protein (OR: 0.08, 95%CI: 0.03, 0.23; <i>p</i>-value &lt; 0.001) and about four times higher for those in the highest tertile of the PRAL (OR: 4.16, 95%CI: 1.94, 8.91; <i>p</i>-value &lt; 0.001) and NEAP scores (OR: 3.57, 95%CI: 1.69, 7.53; <i>p</i>-value &lt; 0.001), compared to those in the lowest tertile. After further adjusting for sodium, saturated fatty acid, and fiber intake, the results remained significant for total plant-based protein intake (OR: 0.07, 95%CI: 0.01, 0.38; <i>p</i>-value = 0.002). In conclusion, a higher NEAP or PRAL score may be associated with increased odds of MS, while a higher intake of plant-based protein instead of animal-based protein may be protective.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSaeedirad, Z.; Ariyanfar, S.; Noormohammadi, M.; Ghorbani, Z.; Naser Moghadasi, A.; Shahemi, S.; Ghanaatgar, M.; Rezaeimanesh, N.; Hekmatdoost, A.; Ghaemi, A.; Razeghi Jahromi, S. Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case-Control Study. Nutrients 2023, 15, 3311.en
dc.identifier.doihttps://doi.org/10.3390/nu15153311en
dc.identifier.urihttp://hdl.handle.net/10919/116024en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmultiple sclerosisen
dc.subjectdietary acid loaden
dc.subjectpotential renal acid loaden
dc.subjectnet endogenous acid productionen
dc.subjectplant-based proteinen
dc.subjectanimal-based proteinen
dc.subjectcase–control studyen
dc.titleHigher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case-Control Studyen
dc.title.serialNutrientsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nutrients-15-03311.pdf
Size:
289.19 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Open Access Subvention Fund Articles
Scholarly Works, Human Nutrition, Foods, and Exercise