Post-training stimulation of the right dorsolateral prefrontal cortex impairs working memory training performance

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dc.contributor.authorAu, Jackyen
dc.contributor.authorKatz, Benjaminen
dc.contributor.authorMoon, Austinen
dc.contributor.authorTalati, Sheebanien
dc.contributor.authorAbagis, Tessa R.en
dc.contributor.authorJonides, Johnen
dc.contributor.authorJaeggi, Susanne M.en
dc.date.accessioned2022-01-12T19:48:09Zen
dc.date.available2022-01-12T19:48:09Zen
dc.date.issued2021-10en
dc.date.updated2022-01-12T19:48:07Zen
dc.description.abstractResearch investigating transcranial direct current stimulation (tDCS) to enhance cognitive training augments both our understanding of its long-term effects on cognitive plasticity as well as potential applications to strengthen cognitive interventions. Previous work has demonstrated enhancement of working memory training while applying concurrent tDCS to the dorsolateral prefrontal cortex (DLPFC). However, the optimal stimulation parameters are still unknown. For example, the timing of tDCS delivery has been shown to be an influential variable that can interact with task learning. In the present study, we used tDCS to target the right DLPFC while participants trained on a visuospatial working memory task. We sought to compare the relative efficacy of online stimulation delivered during training to offline stimulation delivered either immediately before or afterwards. We were unable to replicate previously demonstrated benefits of online stimulation; however, we did find evidence that offline stimulation delivered after training can actually be detrimental to training performance relative to sham. We interpret our results in light of evidence suggesting a role of the right DLPFC in promoting memory interference, and conclude that while tDCS may be a promising tool to influence the results of cognitive training, more research and an abundance of caution are needed before fully endorsing its use for cognitive enhancement. This work suggests that effects can vary substantially in magnitude and direction between studies, and may be heavily dependent on a variety of intervention protocol parameters such as the timing and location of stimulation delivery, about which our understanding is still nascent.en
dc.description.versionAccepted versionen
dc.format.extentPages 2351-2363en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1002/jnr.24784en
dc.identifier.eissn1097-4547en
dc.identifier.issn0360-4012en
dc.identifier.issue10en
dc.identifier.orcidKatz, Benjamin [0000-0002-5612-7540]en
dc.identifier.otherPMC8273206en
dc.identifier.otherNIHMS1681788en
dc.identifier.urihttp://hdl.handle.net/10919/107575en
dc.identifier.volume99en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/33438297en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectcognitive trainingen
dc.subjectconsolidationen
dc.subjectmemory interferenceen
dc.subjectoffline tDCSen
dc.subjectonline tDCSen
dc.subjectstimulation timingen
dc.subjecttranscranial direct current stimulationen
dc.subjectNeurology & Neurosurgeryen
dc.subject1109 Neurosciencesen
dc.subject1701 Psychologyen
dc.titlePost-training stimulation of the right dorsolateral prefrontal cortex impairs working memory training performanceen
dc.title.serialJournal of Neuroscience Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dc.type.otherResearch Support, U.S. Gov't, Non-P.H.S.en
dc.type.otherResearch Support, N.I.H., Extramuralen
dcterms.dateAccepted2020-12-23en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Liberal Arts and Human Sciencesen
pubs.organisational-group/Virginia Tech/Liberal Arts and Human Sciences/Human Development and Family Scienceen
pubs.organisational-group/Virginia Tech/Liberal Arts and Human Sciences/CLAHS T&R Facultyen

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