Comparative evolution of mipafox-induced delayed neuropathy in the rat and hen

Simple item page
dc.contributor.authorCarboni, Deborah Annen
dc.contributor.committeechairJortner, Bernard S.en
dc.contributor.committeememberDyer, Karen R.en
dc.contributor.committeememberEhrich, Marion F.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T21:51:08Zen
dc.date.adate2009-12-05en
dc.date.available2014-03-14T21:51:08Zen
dc.date.issued1993-08-09en
dc.date.rdate2009-12-05en
dc.date.sdate2009-12-05en
dc.description.abstractThe group of chemicals designated organophosphorus compounds have had a significant impact on modern life, including use as pesticides, industrial plasticizers and chemical warfare agents. Exposure to certain organophosphates produces a delayed degeneration of the longest and largest nerve fibers, including those of the ascending and descending tracts of the spinal cord, a condition termed organophosphorus ester-induced delayed neuropathy (OPIDN). Recorded incidents of such an effect in humans have led to research regarding this neurological disease. Among the OPIDN-inducing agents is mipafox, an organophosphate insecticide, the compound we chose to employ in our studies. Although the hen is the primary experimental model in the safety assessment of organophosphates, current research has suggested that the rat may have some validity as an experimental model. We examined the sequential neuropathic effects of a single dose of mipafox (30mg/kg) in rats and hens on a comparative basis to determine the better experimental model.en
dc.description.degreeMaster of Scienceen
dc.format.extentxv, 135 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-12052009-020159en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12052009-020159/en
dc.identifier.urihttp://hdl.handle.net/10919/46144en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1993.C372.pdfen
dc.relation.isformatofOCLC# 29250946en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1993.C372en
dc.subject.lcshChickens -- Effect of insecticides onen
dc.subject.lcshNeuropathyen
dc.subject.lcshOrganophosphorus compounds -- Physiological effecten
dc.subject.lcshRats -- Effect of insecticides onen
dc.titleComparative evolution of mipafox-induced delayed neuropathy in the rat and henen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
LD5655.V855_1993.C372.pdf
Size:
92.02 MB
Format:
Adobe Portable Document Format
Download

Collections

Masters Theses