Factorial design for a sequential allocation study

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dc.contributor.authorEckert, Robert Vernonen
dc.contributor.committeechairFreund, Rudolf J.en
dc.contributor.departmentStatisticsen
dc.date.accessioned2014-03-14T21:41:52Zen
dc.date.adate2012-08-01en
dc.date.available2014-03-14T21:41:52Zen
dc.date.issued1961-12-05en
dc.date.rdate2012-08-01en
dc.date.sdate2012-08-01en
dc.description.abstractRobert J. Taylor and Herbert A. David developed a new experimental approach in the screening of prospective drugs to be used in the treatment of cancer. The procedure is a sequential one, where the allocation of patients to drugs is based upon the performance of the drugs in immediately previous periods. Taylor further developed a computer program to study the effectiveness of the procedure by means of simulated trials. The purpose of this paper has been to study the sequential allocation procedure further by means of simulation in the form of a factorial experiment. Of primary concern has been the behavior of different weighting functions operating under varying experimental conditions. Response variables have been studied as a means for evaluating the effectiveness of the procedure. The results of this experiment are comparable with the findings originally presented by Taylor and David.en
dc.description.degreeMaster of Scienceen
dc.format.extent68 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-08012012-040115en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08012012-040115/en
dc.identifier.urihttp://hdl.handle.net/10919/44046en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1961.E343.pdfen
dc.relation.isformatofOCLC# 22576683en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1961.E343en
dc.subject.lcshDrugs -- Testing -- Mathematical modelsen
dc.subject.lcshFactorial experiment designsen
dc.titleFactorial design for a sequential allocation studyen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineStatisticsen
thesis.degree.grantorVirginia Polytechnic Instituteen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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