Effects of Acute Nutritional Deprivation on Lymphocyte Subsets and Membrane Function in Cats

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dc.contributor.authorFreitag, Kimberly A.en
dc.contributor.committeechairThomas, Elizabeth A.en
dc.contributor.committeememberBarbeau, William E.en
dc.contributor.committeememberSaker, Korinn E.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2014-03-14T21:52:54Zen
dc.date.adate1998-04-29en
dc.date.available2014-03-14T21:52:54Zen
dc.date.issued1998-04-10en
dc.date.rdate1999-04-29en
dc.date.sdate1998-04-10en
dc.description.abstractIdentification of patients with suboptimal nutritional status allows for early treatment intervention. Currently, no definitive test of nutritional status exists. Therefore, this study was conducted to identify possible functional indicators of acute nutritional deprivation. The effects of total nutritional deprivation and subsequent refeeding on lymphocyte functions and subpopulations were examined in 23 healthy cats. Peripheral blood samples were analyzed at various times during fasting and refeeding periods. During the fasting period, decreases were observed in leukocyte number (day 4; p < 0.04), lymphocyte number (p < 0.02), CD4+ cells (day 4; p < 0.06), CD4:CD8 ratio (0 hours; p < 0.004), and mitogen stimulated CD4:CD8 ratio (72 hours; p < 0.15) during the fasting period as compared to baseline. Increases were seen in CD4+ cells (day 7; p < 0.09), CD8+ cells (day 7; p < 0.04) and intracellular calcium (day 4; p < 0.02) as compared to baseline. During the refeeding period increases (p < 0.05) were observed in leukocyte number, CD4+ cells, CD8+ cells, lymphocyte proliferation (p < 0.07) and lymphocyte number (p < 0.004) as compared to day 7. These findings suggest that 7 days starvation had immunosuppressive effects on cats which were alleviated during 7 days refeeding. The use of CD4:CD8 ratio in conjunction with intracellular calcium flux may be useful as indices of nutritional status.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-32998-105852en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-32998-105852/en
dc.identifier.urihttp://hdl.handle.net/10919/46484en
dc.publisherVirginia Techen
dc.relation.haspartCHAP1.PDFen
dc.relation.haspartCHAP2.PDFen
dc.relation.haspartMAN.PDFen
dc.relation.haspartCHAP4.PDFen
dc.relation.haspartLIT5.PDFen
dc.relation.haspartFINALTABLE.PDFen
dc.relation.haspartAPPB.PDFen
dc.relation.haspartMETHAPP.PDFen
dc.relation.haspartVITA.PDFen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectCD4en
dc.subjectCD8en
dc.subjectstarvationen
dc.subjectcalciumen
dc.titleEffects of Acute Nutritional Deprivation on Lymphocyte Subsets and Membrane Function in Catsen
dc.typeThesisen
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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