Plasma N-terminal Proatrial Natriuretic Peptide Concentration in Cats with Hypertrophic Cardiomyopathy

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dc.contributor.authorMacLean, Heidi Normaen
dc.contributor.committeechairAbbott, Jonathan A.en
dc.contributor.committeememberPyle, Robert Leeen
dc.contributor.committeememberHuckle, William R.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T20:32:50Zen
dc.date.adate2004-03-26en
dc.date.available2014-03-14T20:32:50Zen
dc.date.issued2004-03-12en
dc.date.rdate2012-10-01en
dc.date.sdate2004-03-24en
dc.description.abstractObjective: We sought to determine N-terminal proatrial natriuretic peptide concentrations [Nt-proANP] in plasma from cats with hypertrophic cardiomyopathy (HCM). Secondarily, we wished to evaluate the relationship between [Nt-proANP] and echocardiographic variables. Methods: Venous blood samples were obtained from seventeen cats with HCM and from nineteen healthy cats. Plasma [Nt-proANP] was determined using an ELISA assay. The relationship between plasma [Nt-proANP] and M-mode, 2-dimensional and Doppler echocardiographic variables was evaluated. Cats that were hyperthyroid or had evidence of renal disease were excluded from the study. Results: The mean plasma [Nt-proANP] was higher in cats with HCM (3.81 +/- 1.23 pmol/l) than in control cats (3.08 +/- 1.41 pmol/l); however, this difference was not statistically significant (p=0.17). There was a significant correlation between plasma [Nt-proANP] and left ventricular posterior wall thickness (r = 0.42; p=0.01). Additionally, plasma [Nt-proANP] was correlated with left atrial size (r = 0.35; p=0.03). A linear regression model was developed to further explore these relationships. LAs2D and LVPWd had an interactive effect on plasma [Nt-proANP] (R2 = 0.2737; p= 0.02). There was no correlation between any other echocardiographic variable and plasma [Nt-proANP]. There was no correlation between plasma [Nt-proANP] and heart rate (HR), body-weight, or age. Conclusions: Cats with HCM do not have significantly higher plasma [Nt-proANP] than normal cats. There was a significant linear relationship between [Nt-proANP] and LAs2D, LVPWd and the model that described their interaction.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-03242004-165009en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-03242004-165009/en
dc.identifier.urihttp://hdl.handle.net/10919/31538en
dc.publisherVirginia Techen
dc.relation.haspartANP_macLean_thesis_final[1].pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecthypertrophic cardiomyopathyen
dc.subjectdiastolic dysfunctionen
dc.subjectfelineen
dc.subjectatrial natriuretic peptideen
dc.titlePlasma N-terminal Proatrial Natriuretic Peptide Concentration in Cats with Hypertrophic Cardiomyopathyen
dc.typeThesisen
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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