Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue

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dc.contributor.authorMin, So Yunen
dc.contributor.authorLearnard, Heatheren
dc.contributor.authorKant, Shashien
dc.contributor.authorGealikman, Olgaen
dc.contributor.authorRojas-Rodriguez, Razielen
dc.contributor.authorDeSouza, Tiffanyen
dc.contributor.authorDesai, Ananden
dc.contributor.authorKeaney, John F.en
dc.contributor.authorCorvera, Silviaen
dc.contributor.authorCraige, Siobhan M.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2019-04-29T12:24:15Zen
dc.date.available2019-04-29T12:24:15Zen
dc.date.issued2019-04-25en
dc.date.updated2019-04-29T10:49:01Zen
dc.description.abstractExercise mitigates chronic diseases such as diabetes, cardiovascular diseases, and obesity; however, the molecular mechanisms governing protection from these diseases are not completely understood. Here we demonstrate that exercise rescues metabolically compromised high fat diet (HFD) fed mice, and reprograms subcutaneous white adipose tissue (scWAT). Using transcriptomic profiling, scWAT was analyzed for HFD gene expression changes that were rescued by exercise. Gene networks involved in vascularization were identified as prominent targets of exercise, which led us to investigate the vasculature architecture and endothelial phenotype. Vascular density in scWAT was found to be compromised in HFD, and exercise rescued this defect. Similarly, angiogenic capacity as measured by ex vivo capillary sprouting was significantly promoted with exercise. Together, these data demonstrate that exercise enhances scWAT vascularization and functional capacity for angiogenesis, and can prevent the detrimental effects of HFD. The improvement in these indices correlates with improvement of whole-body metabolism, suggesting that scWAT vascularization may be a potential therapeutic target for metabolic disease.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMin, S.Y.; Learnard, H.; Kant, S.; Gealikman, O.; Rojas-Rodriguez, R.; DeSouza, T.; Desai, A.; Keaney, J.F., Jr.; Corvera, S.; Craige, S.M. Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue. Int. J. Mol. Sci. 2019, 20, 2046.en
dc.identifier.doihttps://doi.org/10.3390/ijms20082046en
dc.identifier.urihttp://hdl.handle.net/10919/89230en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectadipose tissueen
dc.subjectangiogenesisen
dc.subjectexerciseen
dc.subjectglucose homeostasisen
dc.subjecthigh-fat dieten
dc.subjectmetabolismen
dc.titleExercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissueen
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
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