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Genetic duplication in Salmonella typhimurium

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dc.contributor.authorWinfield, Suzanne L.en
dc.contributor.departmentMicrobiologyen
dc.date.accessioned2016-04-21T15:34:35Zen
dc.date.available2016-04-21T15:34:35Zen
dc.date.issued1979en
dc.description.abstractA gene duplication occurs in Salmonella typhimurium which involves about 30% of the genome. The frequency of formation and loss of this duplication was determined in a Rec.A⁻ strain and a PolA⁻ strain and compared to that of a RecA⁺, PolA⁺ strain. The frequency of formation was found to be reduced in both RecA⁻ and PolA⁻. strains. Loss of the duplication was eliminated in the RecA⁻ strain, while the frequency of loss was found to be greater in a PolA⁻ strain than in the PolA⁺ strain. The effect of UV irradiation on the formation of duplication was also compared for the three strains. There is an increase in the frequency of formation in both the PolA⁺, RecA⁺ and PolA⁻, RecA⁺ strains, the increase being greater in the PolA⁻ strain. The frequency of formation is reduced in the RecA⁻ strain. It is postulated that recA-dependent repair pathways are involved in the formation of the duplication, but there is at least one other pathway available.en
dc.description.degreeMaster of Scienceen
dc.format.extentiv, 58, [1] leavesen
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttp://hdl.handle.net/10919/70470en
dc.language.isoen_USen
dc.publisherVirginia Polytechnic Institute and State Universityen
dc.relation.isformatofOCLC# 5526141en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1979.W564en
dc.subject.lcshSalmonella typhimuriumen
dc.subject.lcshMicrobial mutationen
dc.titleGenetic duplication in Salmonella typhimuriumen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineMicrobiologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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