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Dietary manipulation causes childhood obesity-like characteristics in pigs

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dc.contributor.authorFisher, Kimberly Deniseen
dc.contributor.committeechairGerrard, David E.en
dc.contributor.committeememberScheffler, Jason M.en
dc.contributor.committeememberEscobar, Jefferyen
dc.contributor.committeememberJiang, Honglinen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2014-03-14T20:50:00Zen
dc.date.adate2012-01-18en
dc.date.available2014-03-14T20:50:00Zen
dc.date.issued2011-12-01en
dc.date.rdate2012-01-18en
dc.date.sdate2011-12-15en
dc.description.abstractAn animal model to study complications resulting from childhood obesity is lacking. Our objective was to develop a porcine model for studying mechanisms underlying diet-induced childhood obesity. Pre-pubertal female pigs, age 35 d, were fed a high-energy diet (HED; n = 12), containing tallow and refined sugars, or a control corn-based diet (n = 11) for 16 wk. Initially, HED pigs self-regulated energy intake similar to controls, but, by wk 5, consumed more (P < 0.001) energy per kg body weight. At wk 15 and 22, pigs were subjected to an oral glucose tolerance test (OGTT); blood glucose increased (P < 0.05) in control pigs and returned to baseline levels within 60 min. HED pigs were hyperglycemic at time 0, and blood glucose did not return to baseline (P = 0.01), even 3 h post-challenge. During OGTT, glucose area under the curve was higher and insulin area under the curve was lower in HED pigs compared to controls (P = 0.001). Pigs given 6 wk of dietary intervention, consuming a control diet, marginally improved glucose area under the curve and LDL-cholesterol although insulin area under the curve was unaffected. Chronic HED intake increased (P < 0.05) subcutaneous, intramuscular, and perirenal fat deposition, and induced hyperglycemia, hypoinsulinemia, and low-density lipoprotein hypercholesterolemia; however, a 6 wk dietary intervention partially recovered a normal physiology. These data suggest pre-pubertal pigs fed HED are a viable animal model for studying childhood obesity.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-12152011-123225en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12152011-123225/en
dc.identifier.urihttp://hdl.handle.net/10919/36176en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartFisher_KD_T_2011.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecthypercholesterolemiaen
dc.subjecthypoinsulinemiaen
dc.subjectadiposityen
dc.subjectmetabolic syndromeen
dc.subjecthyperglycemiaen
dc.titleDietary manipulation causes childhood obesity-like characteristics in pigsen
dc.typeThesisen
thesis.degree.disciplineAnimal and Poultry Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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