Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies

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dc.contributor.authorGraybill, Philip M.en
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.departmentMechanical Engineeringen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2020-05-14T17:47:56Zen
dc.date.available2020-05-14T17:47:56Zen
dc.date.issued2020-04-30en
dc.date.updated2020-05-14T13:55:59Zen
dc.description.abstractPulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation. In addition to well-known membrane effects, PEFs can cause profound cytoskeletal disruption. In this review, we summarize the current understanding of cytoskeletal disruption after PEFs. Compiling available studies, we describe PEF-induced cytoskeletal disruption and possible mechanisms of disruption. Additionally, we consider how cytoskeletal alterations contribute to cell–cell and cell–substrate disruption. We conclude with a discussion of cytoskeletal disruption-induced anti-vascular effects of PEFs and consider how a better understanding of cytoskeletal disruption after PEFs may lead to more effective therapies.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGraybill, P.M.; Davalos, R.V. Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies. Cancers 2020, 12, 1132.en
dc.identifier.doihttps://doi.org/10.3390/cancers12051132en
dc.identifier.urihttp://hdl.handle.net/10919/98391en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectpulsed electric fieldsen
dc.subjectelectroporationen
dc.subjectcytoskeletonen
dc.subjectactinen
dc.subjectmicrotubulesen
dc.subjectintermediate filamentsen
dc.subjectcell junctionsen
dc.subjectnsPEFsen
dc.subjectIREen
dc.subjectECTen
dc.subjectmechanobiologyen
dc.subjectvascular locken
dc.subjectcanceren
dc.titleCytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapiesen
dc.title.serialCancersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Scholarly Works, Biomedical Engineering and Mechanics
Scholarly Works, Mechanical Engineering
Scholarly Works, School of Biomedical Engineering and Sciences