The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

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dc.contributor.authorCao, Changen
dc.contributor.authorChowdhury, Vishwajit S.en
dc.contributor.authorCline, Mark A.en
dc.contributor.authorGilbert, Elizabeth R.en
dc.date.accessioned2022-06-16T20:44:45Zen
dc.date.available2022-06-16T20:44:45Zen
dc.date.issued2021-10-20en
dc.description.abstractHeat stress is a global issue for the poultry industries with substantial annual economic losses and threats to bird health and welfare. When chickens are exposed to high ambient temperatures, like other species they undergo multiple physiological alterations, including behavioral changes, such as cessation of feeding, initiation of a stress signaling cascade, and intestinal immune, and inflammatory responses. The brain and gut are connected and participate in bidirectional communication via the nervous and humoral systems, this network collectively known as the gut-brain axis. Moreover, heat stress not only induces hyperthermia and oxidative stress at the gut epithelium, leading to impaired permeability and then susceptibility to infection and inflammation, but also alters the composition and abundance of the microbiome. The gut microflora, primarily via bacterially derived metabolites and hormones and neurotransmitters, also communicate via similar pathways to regulate host metabolic homeostasis, health, and behavior. Thus, it stands to reason that reshaping the composition of the gut microbiota will impact intestinal health and modulate host brain circuits via multiple reinforcing and complementary mechanisms. In this review, we describe the structure and function of the microbiota-gut-brain axis, with an emphasis on physiological changes that occur in heat-stressed poultry.en
dc.description.sponsorshipFunding for this work was provided in part by the Virginia Agricultural Experiment Station and the Hatch Program of the National Institute of Food and Agriculture, US Department of Agriculture.en
dc.description.versionPublished versionen
dc.format.extent11 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCao C, Chowdhury VS, Cline MA and Gilbert ER (2021) The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review. Front. Physiol. 12:752265. doi: 10.3389/fphys.2021.752265en
dc.identifier.doihttps://doi.org/10.3389/fphys.2021.752265en
dc.identifier.urihttp://hdl.handle.net/10919/110815en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectheat stressen
dc.subjectmicrobiota-gut-brain axisen
dc.subjectanorexiaen
dc.subjectimmune responseen
dc.subjectpoultryen
dc.titleThe Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Reviewen
dc.title.serialFrontiers In Physiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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