Canine Cancer Screening Via Ultraviolet Absorbance And Fluorescence Spectroscopy Of Serum Proteins

dc.contributor.authorDickerson, Bryan Douglasen
dc.contributor.authorGeist, Brian L.en
dc.contributor.authorSpillman, William B. Jr.en
dc.contributor.authorRobertson, John L.en
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentPhysicsen
dc.contributor.departmentBiomedical Engineering and Sciencesen
dc.date.accessed2014-02-24en
dc.date.accessioned2014-04-04T15:12:12Zen
dc.date.available2014-04-04T15:12:12Zen
dc.date.issued2007-01-01en
dc.description.abstractA cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, more accurate estimations of the concentrations of albumin, globulins, and hemoglobin in serum were obtained by fitting the near UV absorbance and photoluminescence spectra of diluted serum as a linear combination of component reference spectra. Tracking these serum proteins over the course of treatment helped to monitor patient immune response to carcinoma and therapy. For cancer screening, 70% of dogs with clinical presentation of cancer displayed suppressed serum hemoglobin levels (below 20 mg/dL) in combination with atypical serum protein compositions, that is, albumin levels outside of a safe range (from 4 to 8 g/dL) and globulin levels above or below a more normal range (from 1.7 to 3.7 g/dL). Of the dogs that met these criteria, only 20% were given a false positive label by this cancer screening test. (C) 2007 Optical Society of America.en
dc.description.sponsorshipVirginia Tech Applied Biosciences Centeren
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBryan D. Dickerson, Brian L. Geist, William B. Spillman, Jr., and John L. Robertson, "Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins," Appl. Opt. 46, 8080-8088 (2007). doi: 10.1364/ao.46.008080en
dc.identifier.doihttps://doi.org/10.1364/ao.46.008080en
dc.identifier.issn1559-128Xen
dc.identifier.urihttp://hdl.handle.net/10919/46878en
dc.identifier.urlhttp://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-33-8080en
dc.language.isoenen
dc.publisherOptical Society of Americaen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectClinical-implicationsen
dc.subjectBiomarkersen
dc.subjectProteomicsen
dc.subjectCarcinomaen
dc.subjectDiagnosisen
dc.subjectBladderen
dc.subjectTumorsen
dc.subjectHemeen
dc.titleCanine Cancer Screening Via Ultraviolet Absorbance And Fluorescence Spectroscopy Of Serum Proteinsen
dc.title.serialApplied Opticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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