Conformal Additive Manufacturing for Organ Interface

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dc.contributor.authorSingh, Manjoten
dc.contributor.committeechairJohnson, Blakeen
dc.contributor.committeememberKong, Zhenyuen
dc.contributor.committeememberRobertson, John L.en
dc.contributor.departmentIndustrial and Systems Engineeringen
dc.date.accessioned2018-12-01T07:01:05Zen
dc.date.available2018-12-01T07:01:05Zen
dc.date.issued2017-06-08en
dc.description.abstractThe inability to monitor the molecular trajectories of whole organs throughout the clinically relevant ischemic interval is a critical problem underlying the organ shortage crisis. Here, we report a novel technique for fabricating manufacturing conformal microfluidic devices for organ interface. 3D conformal printing was leveraged to engineer and fabricate novel organ-conforming microfluidic devices that endow the interface between microfluidic channels and the organ cortex. Large animal studies reveal microfluidic biopsy samples contain rich diagnostic information, including clinically relevant biomarkers of ischemic pathophysiology. Overall, these results suggest microfluidic biopsy via 3D printed organ-conforming microfluidic devices could shift the paradigm for whole organ preservation and assessment, thereby relieving the organ shortage crisis through increased availability and quality of donor organs.en
dc.description.abstractgeneralOrgan failure is one of the most common cause of morbidity and mortality in humans. Unfortunately, there are not enough donor organs to meet the present demand, often referred to as the organ shortage crisis. To compound the problem, there is lack of understanding of the biological processes occurring in organs during the transplantation interval. Here, we present a method to manufacture a biomedical device using a 3D printing technique to monitor, collect, and isolate diagnostically relevant biological species released during the transplantation interval. This information has the potential to lead to a better understanding of organ health, which ultimately could increase the availability and quality of donor organs.en
dc.description.degreeMaster of Scienceen
dc.format.mediumETDen
dc.identifier.othervt_gsexam:11948en
dc.identifier.urihttp://hdl.handle.net/10919/86202en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectbiomanufacturingen
dc.subjectmicrofluidicsen
dc.subject3D printingen
dc.subjectorgan health assessmenten
dc.titleConformal Additive Manufacturing for Organ Interfaceen
dc.typeThesisen
thesis.degree.disciplineIndustrial and Systems Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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