Understanding the complex patterns observed during hepatitis B Virus therapy

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dc.contributor.authorRodriguez, Andrea Carracedoen
dc.contributor.authorChung, Matthiasen
dc.contributor.authorCiupe, Stanca M.en
dc.contributor.departmentMathematicsen
dc.date.accessioned2017-07-31T14:36:41Zen
dc.date.available2017-07-31T14:36:41Zen
dc.date.issued2017-05-19en
dc.description.abstractData from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus decay and rebound. Monte Carlo sampling of the parameter space was used to determine the virological, pharmacological and immunological factors that separate the bi-phasic and tri-phasic virus profiles. We found that the level of liver infection at the start of therapy best separates the decay patterns. Moreover, drug efficacy, ratio between division of uninfected and infected cells, and the strength of cytotoxic immune response are important in assessing the amount of liver damage experienced over time and in quantifying the duration of therapy leading to virus resolution in each of the observed profiles.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCarracedo Rodriguez, A.; Chung, M.; Ciupe, S.M. Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy. Viruses 2017, 9, 117.en
dc.identifier.doihttps://doi.org/10.3390/v9050117en
dc.identifier.issue5en
dc.identifier.urihttp://hdl.handle.net/10919/78479en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectvirus kineticsen
dc.subjectHepatitis B virus (HBV)en
dc.subjectdrug therapyen
dc.subjectMonte Carloen
dc.titleUnderstanding the complex patterns observed during hepatitis B Virus therapyen
dc.title.serialVirusesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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