Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice
| dc.contributor.author | Wu, Po-Chang | en |
| dc.contributor.author | Lin, Shih-Chao | en |
| dc.contributor.author | Panny, Lauren | en |
| dc.contributor.author | Chang, Yu-Kang | en |
| dc.contributor.author | Lin, Chi-Chien | en |
| dc.contributor.author | Tung, Yu-Tang | en |
| dc.contributor.author | Chang, Hen-Hong | en |
| dc.contributor.department | Biomedical Sciences and Pathobiology | en |
| dc.date.accessioned | 2021-06-10T19:36:38Z | en |
| dc.date.available | 2021-06-10T19:36:38Z | en |
| dc.date.issued | 2021-06-07 | en |
| dc.date.updated | 2021-06-10T13:46:36Z | en |
| dc.description.abstract | Sjögren’s syndrome (SS) is an inflammatory autoimmune disease primarily affecting the exocrine glands; it has a major impact on patients’ lives. The Chinese herbal formula SS-1 is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu decoction, which exerts anti-inflammatory, immunomodulatory, and antifibrotic effects. Our previous study demonstrated that SS-1 alleviates clinical SS. This study aimed to evaluate the efficacy and mechanism of the Chinese herbal formula SS-1 for salivary gland protein-induced experimental Sjögren’s syndrome (ESS). These results showed that ESS treatment with the Chinese herbal formula SS-1 (1500 mg/kg) significantly alleviated the severity of ESS. We found that SS-1 substantially improved saliva flow rates in SS mice and ameliorated lymphocytic infiltrations in submandibular glands. In addition, salivary gland protein-induced SS in mice treated with SS-1 significantly lowered proinflammatory cytokines (including IFN-γ, IL-6, and IL-17A) in mouse salivary glands and decreased serum anti-M3R autoantibody levels. In addition, we found that CD4+ T cells isolated from SS-1-treated SS mice significantly reduced the percentages of IFN-γ-producing CD4+ T cells (Th1) and IL-17A-producing CD4+ T cells (Th17). Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Wu, P.-C.; Lin, S.-C.; Panny, L.; Chang, Y.-K.; Lin, C.-C.; Tung, Y.-T.; Chang, H.-H. Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice. Life 2021, 11, 530. | en |
| dc.identifier.doi | https://doi.org/10.3390/life11060530 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/103767 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Sjögren’s syndrome | en |
| dc.subject | Chinese herbal medicine | en |
| dc.subject | SS-1 | en |
| dc.subject | anti-inflammation | en |
| dc.subject | immunomodulation | en |
| dc.title | Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice | en |
| dc.title.serial | Life | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |
| dc.type.dcmitype | StillImage | en |