Improved reference genome of the arboviral vector Aedes albopictus

Simple item page
dc.contributor.authorPalatini, Umbertoen
dc.contributor.authorMasri, Reem A.en
dc.contributor.authorCosme, Luciano V.en
dc.contributor.authorKoren, Sergeyen
dc.contributor.authorThibaud-Nissen, Françoiseen
dc.contributor.authorBiedler, James K.en
dc.contributor.authorKrsticevic, Flaviaen
dc.contributor.authorJohnston, J. Spenceren
dc.contributor.authorHalbach, Rebeccaen
dc.contributor.authorCrawford, Jacob E.en
dc.contributor.authorAntoshechkin, Igoren
dc.contributor.authorFailloux, Anna-Bellaen
dc.contributor.authorPischedda, Elisaen
dc.contributor.authorMarconcini, Micheleen
dc.contributor.authorGhurye, Jayen
dc.contributor.authorRhie, Arangen
dc.contributor.authorSharma, Atashien
dc.contributor.authorKaragodin, Dmitriy A.en
dc.contributor.authorJenrette, Jeremyen
dc.contributor.authorGamez, Stephanieen
dc.contributor.authorMiesen, Pascalen
dc.contributor.authorMasterson, Patricken
dc.contributor.authorCaccone, Adalgisaen
dc.contributor.authorSharakhova, Maria V.en
dc.contributor.authorTu, Zhijian Jakeen
dc.contributor.authorPapathanos, Philippos A.en
dc.contributor.authorVan Rij, Ronald P.en
dc.contributor.authorAkbari, Omar S.en
dc.contributor.authorPowell, Jeffrey R.en
dc.contributor.authorPhillippy, Adam M.en
dc.contributor.authorBonizzoni, Mariangelaen
dc.date.accessioned2020-08-31T11:48:49Zen
dc.date.available2020-08-31T11:48:49Zen
dc.date.issued2020-08-26en
dc.date.updated2020-08-30T03:25:03Zen
dc.description.abstractBackground The Asian tiger mosquito Aedes albopictus is globally expanding and has become the main vector for human arboviruses in Europe. With limited antiviral drugs and vaccines available, vector control is the primary approach to prevent mosquito-borne diseases. A reliable and accurate DNA sequence of the Ae. albopictus genome is essential to develop new approaches that involve genetic manipulation of mosquitoes. Results We use long-read sequencing methods and modern scaffolding techniques (PacBio, 10X, and Hi-C) to produce AalbF2, a dramatically improved assembly of the Ae. albopictus genome. AalbF2 reveals widespread viral insertions, novel microRNAs and piRNA clusters, the sex-determining locus, and new immunity genes, and enables genome-wide studies of geographically diverse Ae. albopictus populations and analyses of the developmental and stage-dependent network of expression data. Additionally, we build the first physical map for this species with 75% of the assembled genome anchored to the chromosomes. Conclusions The AalbF2 genome assembly represents the most up-to-date collective knowledge of the Ae. albopictus genome. These resources represent a foundation to improve understanding of the adaptation potential and the epidemiological relevance of this species and foster the development of innovative control measures.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGenome Biology. 2020 Aug 26;21(1):215en
dc.identifier.doihttps://doi.org/10.1186/s13059-020-02141-wen
dc.identifier.urihttp://hdl.handle.net/10919/99872en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleImproved reference genome of the arboviral vector Aedes albopictusen
dc.title.serialGenome Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
13059_2020_Article_2141.pdf
Size:
1.86 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Thumbnail Image
Name:
13059_2021_Article_2431.pdf
Size:
198.79 KB
Format:
Adobe Portable Document Format
Description:
Correction
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, BioMed Central and SpringerOpen
Destination Area: Global Systems Science (GSS)
Scholarly Works, Entomology
Scholarly Works, Fralin Life Sciences Institute