Mosquito-Borne Viruses and Suppressors of Invertebrate Antiviral RNA Silencing

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dc.contributor.authorO'Neal, Scott T.en
dc.contributor.authorSamuel, Glady Hazithaen
dc.contributor.authorAdelman, Zach N.en
dc.contributor.authorMyles, Kevin M.en
dc.contributor.departmentEntomologyen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2017-09-20T18:21:07Zen
dc.date.available2017-09-20T18:21:07Zen
dc.date.issued2014-11-11en
dc.date.updated2017-09-20T18:21:07Zen
dc.description.abstractThe natural maintenance cycles of many mosquito-borne viruses require establishment of persistent non-lethal infections in the invertebrate host. While the mechanisms by which this occurs are not well understood, antiviral responses directed by small RNAs are important in modulating the pathogenesis of viral infections in disease vector mosquitoes. In yet another example of an evolutionary arms race between host and pathogen, some plant and insect viruses have evolved to encode suppressors of RNA silencing (VSRs). Whether or not mosquito-borne viral pathogens encode VSRs has been the subject of debate. While at first there would seem to be little evolutionary benefit to mosquito-borne viruses encoding proteins or sequences that strongly interfere with RNA silencing, we present here a model explaining how the expression of VSRs by these viruses in the vector might be compatible with the establishment of persistence. We also discuss the challenges associated with interrogating these viruses for the presence of suppressor proteins or sequences, as well as the candidates that have been identified in the genomes of mosquito-borne pathogens thus far.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Neal, S.T.; Samuel, G.H.; Adelman, Z.N.; Myles, K.M. Mosquito-Borne Viruses and Suppressors of Invertebrate Antiviral RNA Silencing. Viruses 2014, 6, 4314-4331.en
dc.identifier.doihttps://doi.org/10.3390/v6114314en
dc.identifier.urihttp://hdl.handle.net/10919/79222en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectRNA silencingen
dc.subjectRNAien
dc.subjectsuppressoren
dc.subjectmosquitoen
dc.subjectinvertebrateen
dc.subjectvirusen
dc.subjectarbovirusen
dc.titleMosquito-Borne Viruses and Suppressors of Invertebrate Antiviral RNA Silencingen
dc.title.serialVirusesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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