Layer-specific mitochondrial diversity across hippocampal CA2 dendrites

dc.contributor.authorPannoni, Katy E.en
dc.contributor.authorGil, Danielaen
dc.contributor.authorCawley, Mikel L.en
dc.contributor.authorAlsalman, Mayd M.en
dc.contributor.authorCampbell, Logan A.en
dc.contributor.authorFarris, Shannonen
dc.date.accessioned2023-03-24T13:45:29Zen
dc.date.available2023-03-24T13:45:29Zen
dc.date.issued2023-02en
dc.description.abstractCA2 is an understudied subregion of the hippocampus that is critical for social memory. Previous studies identified multiple components of the mitochondrial calcium uniporter (MCU) complex as selectively enriched in CA2. The MCU complex regulates calcium entry into mitochondria, which in turn regulates mitochondrial transport and localization to active synapses. We found that MCU is strikingly enriched in CA2 distal apical dendrites, precisely where CA2 neurons receive entorhinal cortical input carrying social information. Furthermore, MCU-enriched mitochondria in CA2 distal dendrites are larger compared to mitochondria in CA2 proximal apical dendrites and neighboring CA1 apical dendrites, which was confirmed in CA2 with genetically labeled mitochondria and electron microscopy. MCU overexpression in neighboring CA1 led to a preferential localization of MCU in the proximal dendrites of CA1 compared to the distal dendrites, an effect not seen in CA2. Our findings demonstrate that mitochondria are molecularly and structurally diverse across hippocampal cell types and circuits, and suggest that MCU can be differentially localized within dendrites, possibly to meet local energy demands.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1002/hipo.23512en
dc.identifier.eissn1098-1063en
dc.identifier.pmid36762797en
dc.identifier.urihttp://hdl.handle.net/10919/114169en
dc.language.isoenen
dc.publisherWileyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdendritesen
dc.subjectentorhinal cortexen
dc.subjecthippocampal CA2en
dc.subjectmitochondrial calcium uniporteren
dc.subjectmitochondrial localizationen
dc.subjectmitochondrial morphologyen
dc.titleLayer-specific mitochondrial diversity across hippocampal CA2 dendritesen
dc.title.serialHippocampusen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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