Mechanical Loading for Modifying Tissue Water Content and Optical Properties

dc.contributor.authorDrew, Christopher W.en
dc.contributor.committeechairRylander, Christopher G.en
dc.contributor.committeememberWest, Robert L. Jr.en
dc.contributor.committeememberWang, Geen
dc.contributor.departmentMechanical Engineeringen
dc.date.accessioned2014-03-14T20:36:40Zen
dc.date.adate2009-06-04en
dc.date.available2014-03-14T20:36:40Zen
dc.date.issued2009-05-04en
dc.date.rdate2009-06-04en
dc.date.sdate2009-05-13en
dc.description.abstractThe majority of the physical properties of tissue depend directly on the interstitial or intracellular concentration of water within the epidermal and dermal layers. The relationship between skin constituent concentrations, such as water and protein, and the mechanical and optical properties of human skin is important to understand its complex nature. Localized mechanical loading has been proven to alter optical properties of tissue, but the mechanisms by which it is accomplished have not been studied in depth. In this thesis, skin's complex nature is investigated experimentally and computationally to give us better insight on how localized mechanical loading changes tissues water content and its optical properties. Load-based compression and subsequent increased optical power transmission through tissue is accomplished to explore a relationship between localized mechanical loading and tissue optical and mechanical properties. Using Optical Coherence Tomography (OCT), modification of optical properties, such as refractive index, are observed to deduce water concentration changes in tissue due to mechanical compression. A computational finite element model is developed to correlate applied mechanical force to tissue strain and water transport. Comprehensive understanding of the underlying physical principles governing the optical property changes within skin due to water concentration variation will enable future development of applications in the engineered tissue optics field.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-05132009-165205en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05132009-165205/en
dc.identifier.urihttp://hdl.handle.net/10919/32714en
dc.publisherVirginia Techen
dc.relation.haspartThesisETDFinal.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectTissueen
dc.subjectCompressionen
dc.subjectWater Contenten
dc.subjectFinite element methoden
dc.subjectDermisen
dc.subjectMechanical Loadingen
dc.titleMechanical Loading for Modifying Tissue Water Content and Optical Propertiesen
dc.typeThesisen
thesis.degree.disciplineMechanical Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
ThesisETDFinal.pdf
Size:
1.81 MB
Format:
Adobe Portable Document Format

Collections