Calculation of the effective atomic number for the iodine contrast agent of the varying concentrations

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dc.contributor.authorPen, Olga Vladimirovnaen
dc.contributor.committeechairCao, Guohuaen
dc.contributor.committeememberBourland, John Danielen
dc.contributor.committeememberLaConte, Stephen M.en
dc.contributor.departmentBiomedical Engineeringen
dc.date.accessioned2017-06-13T19:44:19Zen
dc.date.adate2016-08-04en
dc.date.available2017-06-13T19:44:19Zen
dc.date.issued2016-07-25en
dc.date.rdate2016-08-04en
dc.date.sdate2016-08-04en
dc.description.abstractThe author discusses the difficulties that arise with the determination of the concentration of the iodinated contrast agents in the blood stream via the traditional gray-scale computer tomography and searches for the new imaging modalities that would provide for better sensitivity. The topic of the energy-discriminative color CT is discussed as a potential solution and its suitability is evaluated by performing the experiments on the contrast materials phantom and the phantom containing the iohexol solutions of varying concentrations on the original CT system assembled by the author. A method of the effective atomic number mapping is discussed as a viable alternative to the traditional attenuation-based tomography. The dependency of the effective atomic number of the compound on the energy of the x-ray beam is a phenomenon well recorded in the literature, yet no formal study exists to correctly predict the effective atomic number for a given compound. An extensive physical model is developed based on the previously presented models and adaptations unique to the task in order to determine the effective atomic numbers for exact energies experimentally. The method is tested on different materials. The resultant effective atomic numbers for the water, oil, and iohexol-water solutions of varying concentrations are presented in the study. The effects of the k-edge on both the linear attenuation curve and the effective atomic number curve are discussed. The possible future venues of the research are presented in the final part of the thesis.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-08042016-091408en
dc.identifier.otheretd-08092016-200555en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08042016-091408/en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08092016-200555/en
dc.identifier.urihttp://hdl.handle.net/10919/78149en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecteffective atomic numberen
dc.subjectcolor CTen
dc.subjectx-ray imagingen
dc.subjectiodine contrast agenten
dc.titleCalculation of the effective atomic number for the iodine contrast agent of the varying concentrationsen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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