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Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs

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dc.contributor.authorWhite, David Charlesen
dc.contributor.committeechairWolfe, James F.en
dc.contributor.committeememberCalter, Michael A.en
dc.contributor.committeememberAnderson, Mark R.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:52:58Zen
dc.date.adate1997-08-26en
dc.date.available2014-03-14T21:52:58Zen
dc.date.issued1997-08-21en
dc.date.rdate1998-08-26en
dc.date.sdate1997-08-21en
dc.description.abstractA series of 2-alkyl-3-arylpyrido[2,3-d]pyrimidones were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of these target compounds, we have found that the additional nitrogen at the C-8 position of the quinazolinone framework increased the anticonvulsant activity. However, the neurological toxicity increased as well. The anticonvulsant and neurotoxic activity seen in the variuos 2-alkyl side chains and 3-aryl substituents incorporated into these new pyridopyrimidones was consistent with the activity observed with the same substituents on the 4(3H)-quinazolinones. The 3-aryl group consists of various ortho-substituted phenyl rings, while the 2-alkyl chain consists of a 2-(2-aryl-2-oxo)ethyl or 2-arylethenyl group.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-72297-15249en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-72297-15249/en
dc.identifier.urihttp://hdl.handle.net/10919/46506en
dc.publisherVirginia Techen
dc.relation.haspartdcw2.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectanticonvulsantsen
dc.subjectantiepileptic drugsen
dc.subjectpyridopyrimidonesen
dc.titleSynthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugsen
dc.typeThesisen
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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