Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs
| dc.contributor.author | White, David Charles | en |
| dc.contributor.committeechair | Wolfe, James F. | en |
| dc.contributor.committeemember | Calter, Michael A. | en |
| dc.contributor.committeemember | Anderson, Mark R. | en |
| dc.contributor.department | Chemistry | en |
| dc.date.accessioned | 2014-03-14T21:52:58Z | en |
| dc.date.adate | 1997-08-26 | en |
| dc.date.available | 2014-03-14T21:52:58Z | en |
| dc.date.issued | 1997-08-21 | en |
| dc.date.rdate | 1998-08-26 | en |
| dc.date.sdate | 1997-08-21 | en |
| dc.description.abstract | A series of 2-alkyl-3-arylpyrido[2,3-d]pyrimidones were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of these target compounds, we have found that the additional nitrogen at the C-8 position of the quinazolinone framework increased the anticonvulsant activity. However, the neurological toxicity increased as well. The anticonvulsant and neurotoxic activity seen in the variuos 2-alkyl side chains and 3-aryl substituents incorporated into these new pyridopyrimidones was consistent with the activity observed with the same substituents on the 4(3H)-quinazolinones. The 3-aryl group consists of various ortho-substituted phenyl rings, while the 2-alkyl chain consists of a 2-(2-aryl-2-oxo)ethyl or 2-arylethenyl group. | en |
| dc.description.degree | Master of Science | en |
| dc.identifier.other | etd-72297-15249 | en |
| dc.identifier.sourceurl | http://scholar.lib.vt.edu/theses/available/etd-72297-15249/ | en |
| dc.identifier.uri | http://hdl.handle.net/10919/46506 | en |
| dc.publisher | Virginia Tech | en |
| dc.relation.haspart | dcw2.pdf | en |
| dc.rights | In Copyright | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
| dc.subject | anticonvulsants | en |
| dc.subject | antiepileptic drugs | en |
| dc.subject | pyridopyrimidones | en |
| dc.title | Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs | en |
| dc.type | Thesis | en |
| thesis.degree.discipline | Chemistry | en |
| thesis.degree.grantor | Virginia Polytechnic Institute and State University | en |
| thesis.degree.level | masters | en |
| thesis.degree.name | Master of Science | en |
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