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Fasting and postprandial trimethylamine N-oxide in sedentary and endurance-trained males following a short-term high-fat diet

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dc.contributor.authorSteele, Cortney N.en
dc.contributor.authorBaugh, Mary Elizabethen
dc.contributor.authorGriffin, Laura E.en
dc.contributor.authorNeilson, Andrew P.en
dc.contributor.authorDavy, Brenda M.en
dc.contributor.authorHulver, Matthew W.en
dc.contributor.authorDavy, Kevin P.en
dc.date.accessioned2022-01-28T17:26:41Zen
dc.date.available2022-01-28T17:26:41Zen
dc.date.issued2021-08-01en
dc.date.updated2022-01-28T17:26:40Zen
dc.description.abstractGut bacteria release trimethylamine (TMA) from dietary substrates. TMA is absorbed and is subsequently oxidized in the liver to produce trimethylamine N-oxide (TMAO). Plasma TMAO levels are positively correlated with risk for type 2 diabetes (T2D) and cardiovascular disease (CVD). High-fat diet (HFD) consumption has been reported to increase fasting and postprandial TMAO in sedentary individuals. However, whether the increase in TMAO with consumption of an HFD is observed in endurance-trained males is unknown. Healthy, sedentary (n = 17), and endurance-trained (n = 7) males consumed a 10-day eucaloric diet comprised of 55% carbohydrate, 30% total fat, and <10% saturated fat prior to baseline testing. Blood samples were obtained in a fasted state and for a 4-hour high-fat challenge (HFC) meal at baseline and then again following 5-day HFD (30% carbohydrate, 55% total fat, and 25% saturated fat). Plasma TMAO and TMA-moiety (choline, betaine, L-carnitine) concentrations were measured using isocratic ultraperformance liquid chromatography-tandem mass spectrometry. Age (23 ±3 vs. 22 ± 2 years) and body mass index (23.0 ± 3.0 vs. 23.5 ± 2.1 kg/m2) were similar (both p > 0.05) in the sedentary and endurance-trained group, respectively. VO2max was significantly higher in the endurance-trained compared with sedentary males (56.7 ± 8.2 vs. 39.9 ± 6.0 ml/kg/min). Neither the HFC nor the HFD evoked a detectable change in plasma TMAO (p > 0.05) in either group. Future studies are needed to identify the effects of endurance training on TMAO production.en
dc.description.versionPublished versionen
dc.format.extentPages e14970en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.14814/phy2.14970en
dc.identifier.eissn2051-817Xen
dc.identifier.issn2051-817Xen
dc.identifier.issue16en
dc.identifier.orcidDavy, Brenda [0000-0001-5551-2888]en
dc.identifier.orcidDavy, Kevin [0000-0001-9115-5013]en
dc.identifier.pmid34405585en
dc.identifier.urihttp://hdl.handle.net/10919/107973en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/34405585en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectendurance-traineden
dc.subjecthigh-fat dieten
dc.subjectsedentaryen
dc.subjecttrimethylamine N-oxideen
dc.subject0606 Physiologyen
dc.subject1103 Clinical Sciencesen
dc.subject1116 Medical Physiologyen
dc.titleFasting and postprandial trimethylamine N-oxide in sedentary and endurance-trained males following a short-term high-fat dieten
dc.title.serialPhysiological Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2021-06-16en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/Report testen

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