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Spatiotemporal Regulation of Transcript Isoform Expression in the Hippocampus

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dc.contributor.authorPark, Jounen
dc.contributor.authorFarris, Shannonen
dc.date.accessioned2023-03-09T13:18:20Zen
dc.date.available2023-03-09T13:18:20Zen
dc.date.issued2021-07-08en
dc.date.updated2023-03-08T19:14:49Zen
dc.description.abstractProper development and plasticity of hippocampal neurons require specific RNA isoforms to be expressed in the right place at the right time. Precise spatiotemporal transcript regulation requires the incorporation of essential regulatory RNA sequences into expressed isoforms. In this review, we describe several RNA processing strategies utilized by hippocampal neurons to regulate the spatiotemporal expression of genes critical to development and plasticity. The works described here demonstrate how the hippocampus is an ideal investigative model for uncovering alternate isoform-specific mechanisms that restrict the expression of transcripts in space and time.en
dc.description.versionPublished versionen
dc.format.extent16 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 694234 (Article number)en
dc.identifier.doihttps://doi.org/10.3389/fnmol.2021.694234en
dc.identifier.eissn1662-5099en
dc.identifier.issn1662-5099en
dc.identifier.orcidFarris, Shannon [0000-0003-4473-1684]en
dc.identifier.pmid34305526en
dc.identifier.urihttp://hdl.handle.net/10919/114064en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000675374200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectRNA localizationen
dc.subjectalternative splicingen
dc.subjectsubcellular localizationen
dc.subjecthippocampusen
dc.subjectCdc42en
dc.subjectBDNFen
dc.subjectalternative isoform expressionen
dc.subjectalternate UTRen
dc.subjectBDNF MESSENGER-RNAen
dc.subjectRECTIFYING POTASSIUM CHANNELSen
dc.subjectCREB PHOSPHORYLATIONen
dc.subjectCIRCULAR RNASen
dc.subjectSYNAPTIC-TRANSMISSIONen
dc.subjectSURFACE EXPRESSIONen
dc.subjectUNWINDING ACTIVITYen
dc.subjectMOLECULAR-CLONINGen
dc.subjectSPINE MORPHOLOGYen
dc.subjectRETAINED INTRONen
dc.subjectGeneticsen
dc.titleSpatiotemporal Regulation of Transcript Isoform Expression in the Hippocampusen
dc.title.serialFrontiers in Molecular Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2021-06-15en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology/Otheren
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Secondary Appointment- Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Internal Med-Subgroupen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Biomedical Research Institute at VTCen

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