Mental imagery can generate and regulate acquired differential fear conditioned reactivity

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dc.contributor.authorGreening, Steven G.en
dc.contributor.authorLee, Tae-Hoen
dc.contributor.authorBurleigh, Laurynen
dc.contributor.authorGrégoire, Laurenten
dc.contributor.authorRobinson, Tyleren
dc.contributor.authorJiang, Xinruien
dc.contributor.authorMather, Maraen
dc.contributor.authorKaplan, Jonasen
dc.date.accessioned2022-02-15T05:07:18Zen
dc.date.available2022-02-15T05:07:18Zen
dc.date.issued2022-12-01en
dc.date.updated2022-02-15T05:07:14Zen
dc.description.abstractMental imagery is an important tool in the cognitive control of emotion. The present study tests the prediction that visual imagery can generate and regulate differential fear conditioning via the activation and prioritization of stimulus representations in early visual cortices. We combined differential fear conditioning with manipulations of viewing and imagining basic visual stimuli in humans. We discovered that mental imagery of a fear-conditioned stimulus compared to imagery of a safe conditioned stimulus generated a significantly greater conditioned response as measured by self-reported fear, the skin conductance response, and right anterior insula activity (experiment 1). Moreover, mental imagery effectively down- and up-regulated the fear conditioned responses (experiment 2). Multivariate classification using the functional magnetic resonance imaging data from retinotopically defined early visual regions revealed significant decoding of the imagined stimuli in V2 and V3 (experiment 1) but significantly reduced decoding in these regions during imagery-based regulation (experiment 2). Together, the present findings indicate that mental imagery can generate and regulate a differential fear conditioned response via mechanisms of the depictive theory of imagery and the biased-competition theory of attention. These findings also highlight the potential importance of mental imagery in the manifestation and treatment of psychological illnesses.en
dc.description.versionPublished versionen
dc.format.extentPages 997en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-022-05019-yen
dc.identifier.eissn2045-2322en
dc.identifier.issn2045-2322en
dc.identifier.issue1en
dc.identifier.orcidLee, Tae-Ho [0000-0001-6458-0620]en
dc.identifier.otherPMC8770773en
dc.identifier.other10.1038/s41598-022-05019-y (PII)en
dc.identifier.pmid35046506en
dc.identifier.urihttp://hdl.handle.net/10919/108362en
dc.identifier.volume12en
dc.language.isoenen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35046506en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMental imagery can generate and regulate acquired differential fear conditioned reactivityen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2022-01-03en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Psychologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen

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Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Psychology