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Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

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dc.contributor.authorRasamison, Vincent E.en
dc.contributor.authorRakotondraibe, L. Harinantenainaen
dc.contributor.authorSlebodnick, Carlaen
dc.contributor.authorBrodie, Peggy J.en
dc.contributor.authorRatsimbason, Michaelen
dc.contributor.authorTenDyke, Karenen
dc.contributor.authorShen, Yongchunen
dc.contributor.authorRandrianjanaka, Lucien M.en
dc.contributor.authorKingston, David G. I.en
dc.contributor.departmentChemistryen
dc.contributor.departmentCenter for Drug Discoveryen
dc.date.accessioned2017-01-25T04:02:54Zen
dc.date.available2017-01-25T04:02:54Zen
dc.date.issued2014-05-16en
dc.description.abstractThe new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the non-small lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.en
dc.description.versionPublished versionen
dc.format.extent2626 - 2629 (4) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1021/ol500775ren
dc.identifier.issn1523-7060en
dc.identifier.issue10en
dc.identifier.urihttp://hdl.handle.net/10919/74420en
dc.identifier.volume16en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336199200014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectChemistry, Organicen
dc.subjectChemistryen
dc.subjectLIMONOIDSen
dc.subjectFLORIBUNDAen
dc.subjectMELIACEAEen
dc.subjectOBTUSIFOLIAen
dc.subjectPUBESCENSen
dc.subjectSTEROIDSen
dc.subjectROBUSTAen
dc.subjectHOLSTIIen
dc.titleNitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.en
dc.title.serialOrganic Lettersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Chemistryen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

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