Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

dc.contributor.authorRasamison, Vincent E.en
dc.contributor.authorRakotondraibe, L. Harinantenainaen
dc.contributor.authorSlebodnick, Carlaen
dc.contributor.authorBrodie, Peggy J.en
dc.contributor.authorRatsimbason, Michaelen
dc.contributor.authorTenDyke, Karenen
dc.contributor.authorShen, Yongchunen
dc.contributor.authorRandrianjanaka, Lucien M.en
dc.contributor.authorKingston, David G. I.en
dc.contributor.departmentChemistryen
dc.contributor.departmentCenter for Drug Discoveryen
dc.date.accessioned2017-01-25T04:02:54Zen
dc.date.available2017-01-25T04:02:54Zen
dc.date.issued2014-05-16en
dc.description.abstractThe new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the non-small lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.en
dc.description.versionPublished versionen
dc.format.extent2626 - 2629 (4) page(s)en
dc.identifier.doihttps://doi.org/10.1021/ol500775ren
dc.identifier.issn1523-7060en
dc.identifier.issue10en
dc.identifier.urihttp://hdl.handle.net/10919/74420en
dc.identifier.volume16en
dc.languageEnglishen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336199200014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectChemistry, Organicen
dc.subjectChemistryen
dc.subjectLIMONOIDSen
dc.subjectFLORIBUNDAen
dc.subjectMELIACEAEen
dc.subjectOBTUSIFOLIAen
dc.subjectPUBESCENSen
dc.subjectSTEROIDSen
dc.subjectROBUSTAen
dc.subjectHOLSTIIen
dc.titleNitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.en
dc.title.serialOrganic Lettersen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Chemistryen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Turraea OrgLett Final 04-18-14.pdf
Size:
306.47 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
License bundle
Now showing 1 - 1 of 1
Name:
VTUL_Distribution_License_2016_05_09.pdf
Size:
18.09 KB
Format:
Adobe Portable Document Format
Description: