SARS-CoV-2 virus transfers to skin through contact with contaminated solids

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dc.contributor.authorBehzadinasab, Saeeden
dc.contributor.authorChin, Alex W. H.en
dc.contributor.authorHosseini, Mohsenen
dc.contributor.authorPoon, Leo L. M.en
dc.contributor.authorDucker, William A.en
dc.date.accessioned2021-12-10T15:26:05Zen
dc.date.available2021-12-10T15:26:05Zen
dc.date.issued2021-11-24en
dc.description.abstractTransfer of SARS-CoV-2 from solids to fingers is one step in infection via contaminated solids, and the possibility of infection from this route has driven calls for increased frequency of handwashing during the COVID-19 pandemic. To analyze this route of infection, we measured the percentage of SARS-CoV-2 that was transferred from a solid to an artificial finger. A droplet of SARS-CoV-2 suspension (1 mu L) was placed on a solid, and then artificial skin was briefly pressed against the solid with a light force (3 N). Transfer from a variety of solids was detected, and transfer from the non-porous solids, glass, stainless steel, and Teflon, was substantial when the droplet was still wet. The viral titer for the finger was 13-16% or 0.8-0.9 log less than for the input droplet. Transfer still occurred after the droplet evaporated, but was smaller, 3-9%. We found a lower level of transfer from porous solids but did not find a significant effect of solid wettability for non-porous solids.en
dc.description.notesThe authors acknowledge use of Microscopy facilities within the NCFL at Virginia Tech. We thank Professor Thomas Staley for grinding the glass particles to an appropriate size, Kevin Holshouser for fabricating the transfer apparatus, and Matty Ducker for the linear regression in Figure S13. This work was supported by the National Science Foundation under Grant No. CBET-1902364, the Health and Medical Research Fund (COVID190116), and the National Institute of Allergy and Infectious Diseases (contract HHSN272201400006C).en
dc.description.sponsorshipNational Science FoundationNational Science Foundation (NSF) [CBET-1902364]; Health and Medical Research Fund [COVID190116]; National Institute of Allergy and Infectious DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [HHSN272201400006C]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-021-00843-0en
dc.identifier.issn2045-2322en
dc.identifier.issue1en
dc.identifier.other22868en
dc.identifier.pmid34819522en
dc.identifier.urihttp://hdl.handle.net/10919/106920en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleSARS-CoV-2 virus transfers to skin through contact with contaminated solidsen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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