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Chromosome and Genome Divergence between the Cryptic Eurasian Malaria Vector-Species Anopheles messeae and Anopheles daciae

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dc.contributor.authorNaumenko, Anastasia N.en
dc.contributor.authorKaragodin, Dmitriy A.en
dc.contributor.authorYurchenko, Andrey A.en
dc.contributor.authorMoskaev, Anton V.en
dc.contributor.authorMartin, Olga I.en
dc.contributor.authorBaricheva, Elina M.en
dc.contributor.authorSharakhov, Igor V.en
dc.contributor.authorGordeev, Mikhail I.en
dc.contributor.authorSharakhova, Maria V.en
dc.contributor.departmentEntomologyen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2020-03-02T13:26:44Zen
dc.date.available2020-03-02T13:26:44Zen
dc.date.issued2020-02-05en
dc.date.updated2020-03-02T12:40:04Zen
dc.description.abstractChromosomal inversions are important drivers of genome evolution. The Eurasian malaria vector <i>Anopheles</i> <i>messeae</i> has five polymorphic inversions. A cryptic species, <i>An. daciae</i>, has been discriminated from <i>An. messeae</i> based on five fixed nucleotide substitutions in the internal transcribed spacer 2 (ITS2) of ribosomal DNA. However, the inversion polymorphism in <i>An. daciae</i> and the genome divergence between these species remain unexplored. In this study, we sequenced the ITS2 region and analyzed the inversion frequencies of 289 <i>Anopheles</i> larvae specimens collected from three locations in the Moscow region. Five individual genomes for each of the two species were sequenced. We determined that <i>An. messeae</i> and <i>An. daciae</i> differ from each other by the frequency of polymorphic inversions. Inversion X1 was fixed in <i>An. messeae</i> but polymorphic in <i>An. daciae</i> populations. The genome sequence comparison demonstrated genome-wide divergence between the species, especially pronounced on the inversion-rich X chromosome (mean Fst = 0.331). The frequency of polymorphic autosomal inversions was higher in <i>An. messeae</i> than in <i>An. daciae.</i> We conclude that the X chromosome inversions play an important role in the genomic differentiation between the species. Our study determined that <i>An. messeae</i> and <i>An. daciae</i> are closely related species with incomplete reproductive isolation.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNaumenko, A.N.; Karagodin, D.A.; Yurchenko, A.A.; Moskaev, A.V.; Martin, O.I.; Baricheva, E.M.; Sharakhov, I.V.; Gordeev, M.I.; Sharakhova, M.V. Chromosome and Genome Divergence between the Cryptic Eurasian Malaria Vector-Species Anopheles messeae and Anopheles daciae. Genes 2020, 11, 165.en
dc.identifier.doihttps://doi.org/10.3390/genes11020165en
dc.identifier.urihttp://hdl.handle.net/10919/97094en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmalaria mosquitoesen
dc.subjectpolymorphic inversionsen
dc.subjectgenomeen
dc.subjectinternal transcribed spacer 2en
dc.titleChromosome and Genome Divergence between the Cryptic Eurasian Malaria Vector-Species Anopheles messeae and Anopheles daciaeen
dc.title.serialGenesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Scholarly Works, Entomology
Scholarly Works, Fralin Life Sciences Institute