A Microfabricated Bioimpedance Sensor with Enhanced Sensitivity for Early Breast Cancer Detection

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dc.contributor.authorSrinivasaraghavan, Vaishnavien
dc.contributor.committeechairAgah, Masouden
dc.contributor.committeememberSubbiah, Elankumaranen
dc.contributor.committeememberStrobl, Jeannine S.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2014-03-14T21:51:24Zen
dc.date.adate2012-01-05en
dc.date.available2014-03-14T21:51:24Zen
dc.date.issued2011-12-01en
dc.date.rdate2012-01-05en
dc.date.sdate2011-12-13en
dc.description.abstractBioimpedance is the term given to the complex impedance value that is characteristic of the resistance that biological cells offer to the flow of electric current. The objective of this study is to analyze the differences in the bioimpedance of highly metastatic MDA-MB-231 and normal MCF 10A breast epithelial cells and use this information to detect a very small number of breast cancer cells present in a background of normal breast cells and other cells that are typically present in a human biopsy sample.To accomplish this, a bioimpedance sensor with flat gold microelectrodes on a silicon substrate was designed and fabricated. Suberoylanilide hydroxamic acid (SAHA), an FDA-approved anti-cancer agent was used to improve the sensitivity of the bioimpedance sensor towards cancer cells by selectively modifying their cytoarchitecture.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-12132011-141151en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12132011-141151/en
dc.identifier.urihttp://hdl.handle.net/10919/46202en
dc.publisherVirginia Techen
dc.relation.haspartSrinivasaraghavan_V_T_2011.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectSAHAen
dc.subjectBiosensoren
dc.subjectMicroelectrodesen
dc.subjectBreast Canceren
dc.subjectBioimpedanceen
dc.titleA Microfabricated Bioimpedance Sensor with Enhanced Sensitivity for Early Breast Cancer Detectionen
dc.typeThesisen
thesis.degree.disciplineElectrical and Computer Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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