Baicalein, a novel anti-diabetic compound

Simple item page
dc.contributor.authorFu, Yuen
dc.contributor.committeechairLiu, Dongminen
dc.contributor.committeememberLi, Liwuen
dc.contributor.committeememberHulver, Matthew W.en
dc.contributor.committeememberBarbeau, William E.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-04-04T19:49:44Zen
dc.date.adate2012-09-12en
dc.date.available2017-04-04T19:49:44Zen
dc.date.issued2012-08-08en
dc.date.rdate2016-09-30en
dc.date.sdate2012-08-22en
dc.description.abstractBoth in type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of ?-cells, leading to the impaired insulin secretion. Thus, the search for agents to protect b-cell and enhance its function is important for diabetes treatment. Studies have reported that baicalein, a flavone originally isolated from the roots of Chinese herb Scutellaria baicalensis, has various claimed beneficial effects on health, such as anti-oxidant, anti-viral, anti-thrombotic, and anti-inflammatory effects. However, it is unclear whether it exerts an anti-diabetic action. Here, we present evidence that baicalein may be a novel anti-diabetic agent. Specifically, dietary intake of baicalein significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in high-fat diet (HFD)-fed middle-aged diabetic mice, which was associated with the improved isle t?-cell survival and mass. Baicalein treatment had no effect on food intake, body weight gain, circulating lipid profile, and insulin sensitivity in HFD-fed mice. In in-vitro studies, baicalein significantly augmented glucose-stimulated insulin secretion in insulin-secreting cells (INS1) and promotes viability of INS1 cells and human islets. These results demonstrate that baicalein may be a naturally occurring anti-diabetic agent by directly modulating pancreatic?-cell function.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-08222012-020303en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08222012-020303/en
dc.identifier.urihttp://hdl.handle.net/10919/76854en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectblood glucoseen
dc.subjectinsulinen
dc.subjectdiabetesen
dc.subjectbaicaleinen
dc.subjectpancreatic β-cellen
dc.titleBaicalein, a novel anti-diabetic compounden
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
etd-08222012-020303_Fu_Y_T_2012.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format
Download

Collections

Masters Theses