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Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy

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dc.contributor.authorCarvallo, Francisco R.en
dc.contributor.authorMartins, Mathiasen
dc.contributor.authorJoshi, Lok R.en
dc.contributor.authorCaserta, Leonardo C.en
dc.contributor.authorMitchell, Patrick K.en
dc.contributor.authorCecere, Thomas E.en
dc.contributor.authorHancock, Sandyen
dc.contributor.authorGoodrich, Erin L.en
dc.contributor.authorMurphy, Juliaen
dc.contributor.authorDiel, Diego G.en
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-08-09T16:52:04Zen
dc.date.available2021-08-09T16:52:04Zen
dc.date.issued2021-07-31en
dc.date.updated2021-08-06T15:20:03Zen
dc.description.abstractCoronavirus disease 19 (COVID-19), has claimed millions of human lives worldwide since the emergence of the zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in December 2019. Notably, most severe and fatal SARS-CoV-2 infections in humans have been associated with underlying clinical conditions, including diabetes, hypertension and heart diseases. Here, we describe a case of severe SARS-CoV-2 infection in a domestic cat (<i>Felis catus</i>) that presented with hypertrophic cardiomyopathy (HCM), a chronic heart condition that has been described as a comorbidity of COVID-19 in humans and that is prevalent in domestic cats. The lung and heart of the affected cat presented clear evidence of SARS-CoV-2 replication, with histological lesions similar to those observed in humans with COVID-19 with high infectious viral loads being recovered from these organs. The study highlights the potential impact of comorbidities on the outcome of SARS-CoV-2 infection in animals and provides important information that may contribute to the development of a feline model with the potential to recapitulate the clinical outcomes of severe COVID-19 in humans.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCarvallo, F.R.; Martins, M.; Joshi, L.R.; Caserta, L.C.; Mitchell, P.K.; Cecere, T.; Hancock, S.; Goodrich, E.L.; Murphy, J.; Diel, D.G. Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy. Viruses 2021, 13, 1510.en
dc.identifier.doihttps://doi.org/10.3390/v13081510en
dc.identifier.urihttp://hdl.handle.net/10919/104600en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCOVID-19en
dc.subjectSARS-CoV-2en
dc.subjectcaten
dc.subjecthypertrophic cardiomyopathyen
dc.subjectcomorbidityen
dc.titleSevere SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathyen
dc.title.serialVirusesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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