Evaluation of the effects of clomipramine on the canine hypothalamic-pituitary-thyroid axis

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dc.contributor.authorGulikers, Keven Peteren
dc.contributor.committeechairPanciera, David L.en
dc.contributor.committeememberWilcke, Jeffrey R.en
dc.contributor.committeememberMonroe, William E.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T20:33:52Zen
dc.date.adate2002-05-07en
dc.date.available2014-03-14T20:33:52Zen
dc.date.issued2002-04-08en
dc.date.rdate2012-10-01en
dc.date.sdate2002-04-19en
dc.description.abstractTricyclic antidepressants have been shown to alter thyroid function in man and laboratory animals, but have not been evaluated in the dog. The effect of administration of clomipramine on canine thyroid function was studied in a prospective protocol in which 14 mature, healthy dogs were administered clomipramine (3 mg/kg PO q12h) for 112 days. Thyroid-stimulating hormone (TSH), total thyroxine (T4), total 3,5,3' triiodothyronine (T3), free thyroxine (fT4), and 3,3',5' triiodothyronine (reverse T3; rT3) concentrations were measured on selected days. Thyrotropin-releasing hormone (TRH) response tests were performed concurrently. Repeated measures analysis of variance was applied to test for effects of day of treatment; when significance (p < 0.05) was noted, it was further investigated using orthogonal polynomial trends. Significant decreases were found in serum T4 (26 ± 1.2 to 17 ± 0.5 nmol/L, p < 0.001), fT4, (29 ± 2.4 to 19 ± 1.3 pmol/L, p < 0.0002), and rT3 (1.2 ± 0.1 to 0.83 ± 0.08 nmol/L, p < 0.0001) concentrations. The effect of time on serum T3 concentration was also significant (p < 0.0001), but no consistent trend could be identified. No significant effect of time was noted in either pre- or post-TRH TSH concentrations. The results of this study indicate that significant and substantial decreases in T4 (35%), fT4 (38%), and rT3 can occur during clomipramine administration. Long-term administration of clomipramine may result in a misdiagnosis of hypothyroidism if a dog is tested while taking this medication and, since decreased serum fT4 occurs, hypothyroidism may result.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-04192002-163244en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-04192002-163244/en
dc.identifier.urihttp://hdl.handle.net/10919/31768en
dc.publisherVirginia Techen
dc.relation.haspartThesis.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectthyroxineen
dc.subjecttricyclic antidepressanten
dc.subjectthyroiden
dc.subjecthormoneen
dc.subjectclomipramineen
dc.subjectcanineen
dc.titleEvaluation of the effects of clomipramine on the canine hypothalamic-pituitary-thyroid axisen
dc.typeThesisen
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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