The transfer of endrin via the milk to pine mouse pups and the resultant effects on hepatic microsomal activity

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dc.contributor.authorHundley, Stephen Gilberten
dc.contributor.committeechairWebb, Ryland E.en
dc.contributor.committeememberCampbell, T. Colinen
dc.contributor.committeememberEaton, John L.en
dc.contributor.departmentBiochemistry and Nutritionen
dc.date.accessioned2014-03-14T21:41:07Zen
dc.date.adate2012-07-24en
dc.date.available2014-03-14T21:41:07Zen
dc.date.issued1974-08-05en
dc.date.rdate2012-07-24en
dc.date.sdate2012-07-24en
dc.description.abstractMany lipophilic pesticides are known to be transferred to offspring via the mother's milk. The present study was conducted to determine how much endrin was transferred from endrin resistant and susceptible dams to their suckling pups and to further characterize the effects that endrin may have on the hepatic mixed function oxidase (MFO) system in the pups. Dosing of the dams with endrin began one day after birth with either (l) oral doses of endrin in corn oil or (2) a mixture of endrin in ground feed. The total amount of endrin in the pup was determined by gas chromatography. MFO activity was determined in 2-1/2 week old pups and for adult animals using maximal activities for the demethylation of ethylmorphine and hydroxylation of aniline. No difference in the amount of endrin present in the pups was observed between strains provided both received equal amounts of endrin. MFO activity for endrin dosed mature animals and for 2-1/2 week old pups from endrin dosed dams exhibited a significant decrease from control activities. There was no difference in MFO activities between age groups. A significantly higher ethylmorphine demethylase activity was observed in comparing the resistant to the susceptible strain but there was no significant difference in aniline hydroxylase activity.en
dc.description.degreeMaster of Scienceen
dc.format.extentvi, 47 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-07242012-040021en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07242012-040021/en
dc.identifier.urihttp://hdl.handle.net/10919/43882en
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1974.H84.pdfen
dc.relation.isformatofOCLC# 21882539en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1974.H84en
dc.subject.lcshLiver function testsen
dc.subject.lcshMicrotus pinetorumen
dc.titleThe transfer of endrin via the milk to pine mouse pups and the resultant effects on hepatic microsomal activityen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineBiochemistry and Nutritionen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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