Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

dc.contributor.authorTyson, John J.en
dc.contributor.authorNovak, Belaen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2016-12-09T21:29:17Zen
dc.date.available2016-12-09T21:29:17Zen
dc.date.issued2015-07-01en
dc.description.abstractIn this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms with many kinetic parameters. We describe how the mature models made surprising and informative predictions about the control system that were later confirmed experimentally. Along the way, we comment on the ‘parameter estimation problem’ and conclude with an appeal for a greater role for mathematical models in molecular cell biology.en
dc.description.versionPublished versionen
dc.format.extent10 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1186/s12915-015-0158-9en
dc.identifier.issn1741-7007en
dc.identifier.urihttp://hdl.handle.net/10919/73621en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357153300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiologyen
dc.subjectLife Sciences & Biomedicine - Other Topicsen
dc.subjectMathematical modelsen
dc.subjectMitosis-promoting factoren
dc.subjectCell cycle checkpointsen
dc.subjectRegulated kinasesen
dc.subjectRegulated phosphatasesen
dc.subjectRegulated proteolysisen
dc.subjectMATURATION-PROMOTING FACTORen
dc.subjectXENOPUS-OOCYTE EXTRACTSen
dc.subjectSYSTEMS-LEVEL FEEDBACKen
dc.subjectPROTEIN PHOSPHATASE 2Aen
dc.subjectM-PHASE CONTROLen
dc.subjectEGG EXTRACTSen
dc.subjectFISSION YEASTen
dc.subjectGREATWALL KINASEen
dc.subjectMOLECULAR-MODELen
dc.subjectDIVISION CYCLEen
dc.titleModels in biology: lessons from modeling regulation of the eukaryotic cell cycleen
dc.title.serialBMC Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

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