Cataract formation in young rats as a consequence of maternal diets containing excess phenylalanine and low in tryptophan and/or vitamin E

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dc.contributor.authorHill, James E.en
dc.contributor.committeecochairBunce, George Edwinen
dc.contributor.committeecochairRitchey, Sanford J.en
dc.contributor.committeememberDriskell, Judy A.en
dc.contributor.departmentHuman Nutrition and Foodsen
dc.date.accessioned2014-03-14T21:38:21Zen
dc.date.adate2010-06-12en
dc.date.available2014-03-14T21:38:21Zen
dc.date.issued1977-05-15en
dc.date.rdate2010-06-12en
dc.date.sdate2010-06-12en
dc.description.abstractDiets containing 5.0% excess phenylalanine; 6.0% excess protein (gelatin), and limited in tryptophan (75mg/lOOg) and/or vitamin E (O.lmg/IOOg) were fed to male rats during gestation and lactation. Addition of 5.0% phenylalanine result in a greater incidence of cataract than studies previously reported with diets limited in tryptophan and vitamin E alone, or a single supplementation of Vitamin E (40.0.mg/lOOg). Supplementation with tryptophan (500mg/lOOg) and vitamin E (40.0mg/100g) prevented cataract formation. Replacing the 5.0% excess phenylalanine and 6.0% excess protein (gelatin) with an equivalent of a balanced free amino acid mixture prevented cataract formation in the group supplemented with vitamin E alone. Addition of balanced free amino acids resulted in decreased fertility, pup survival, and increased diuresis. Supplementation with vitamin E (40.0mg/lOOg) alone prevented these effects. Urinary excretions of keto acid (phenylpyruvate), nitrogen, urea, and creatinine were examined during the 7-l4th days of gestation. Amino acid analysis were performed on plasma and soluble lens hornogenates from young progeny. Protein separations of soluble lens homogenates from young progeny were obtained. Analysis of these parameters did not indicate distinct differences between cataractous and noncataractous groups.en
dc.description.degreeMaster of Scienceen
dc.format.extentix, 121 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06122010-020304en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06122010-020304/en
dc.identifier.urihttp://hdl.handle.net/10919/43247en
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1977.H55.pdfen
dc.relation.isformatofOCLC# 39842017en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectvisual impairmenten
dc.subject.lccLD5655.V855 1977.H55en
dc.titleCataract formation in young rats as a consequence of maternal diets containing excess phenylalanine and low in tryptophan and/or vitamin Een
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineHuman Nutrition and Foodsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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