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Genus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traits

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dc.contributor.authorSun, Chengen
dc.contributor.authorHuang, Jiaxingen
dc.contributor.authorWang, Yunen
dc.contributor.authorZhao, Xiaomengen
dc.contributor.authorSu, Longen
dc.contributor.authorThomas, Gregg W. C.en
dc.contributor.authorZhao, Mengyaen
dc.contributor.authorZhang, Xingtanen
dc.contributor.authorJungreis, Irwinen
dc.contributor.authorKellis, Manolisen
dc.contributor.authorVicario, Saverioen
dc.contributor.authorSharakhov, Igor V.en
dc.contributor.authorBondarenko, Semen M.en
dc.contributor.authorHasselmann, Martinen
dc.contributor.authorKim, Chang N.en
dc.contributor.authorPaten, Benedicten
dc.contributor.authorPenso-Dolfin, Lucaen
dc.contributor.authorWang, Lien
dc.contributor.authorChang, Yuxiaoen
dc.contributor.authorGao, Qiangen
dc.contributor.authorMa, Lingen
dc.contributor.authorMa, Linaen
dc.contributor.authorZhang, Zhangen
dc.contributor.authorZhang, Hongboen
dc.contributor.authorZhang, Huahaoen
dc.contributor.authorRuzzante, Livioen
dc.contributor.authorRobertson, Hugh M.en
dc.contributor.authorZhu, Yihuien
dc.contributor.authorLiu, Yanjieen
dc.contributor.authorYang, Huipengen
dc.contributor.authorDing, Leleen
dc.contributor.authorWang, Quanguien
dc.contributor.authorMa, Dongnaen
dc.contributor.authorXu, Weilinen
dc.contributor.authorLiang, Chengen
dc.contributor.authorItgen, Michael W.en
dc.contributor.authorMee, Laurenen
dc.contributor.authorCao, Gangen
dc.contributor.authorZhang, Zeen
dc.contributor.authorSadd, Ben M.en
dc.contributor.authorHahn, Matthew W.en
dc.contributor.authorSchaack, Sarahen
dc.contributor.authorBarribeau, Seth M.en
dc.contributor.authorWilliams, Paul H.en
dc.contributor.authorWaterhouse, Robert M.en
dc.contributor.authorMueller, Rachel Lockridgeen
dc.contributor.departmentEntomologyen
dc.date.accessioned2021-08-05T17:33:59Zen
dc.date.available2021-08-05T17:33:59Zen
dc.date.issued2021-02-01en
dc.date.updated2021-08-05T17:33:56Zen
dc.description.abstractBumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial and solitary life-cycle phases, and some social parasite species, they are especially interesting models to understand social evolution, behavior, and ecology. Reports of many species in decline point to pathogen transmission, habitat loss, pesticide usage, and global climate change, as interconnected causes. These threats to bumblebee diversity make our reliance on a handful of well-studied species for agricultural pollination particularly precarious. To broadly sample bumblebee genomic and phenotypic diversity, we de novo sequenced and assembled the genomes of 17 species, representing all 15 subgenera, producing the first genus-wide quantification of genetic and genomic variation potentially underlying key ecological and behavioral traits. The species phylogeny resolves subgenera relationships, whereas incomplete lineage sorting likely drives high levels of gene tree discordance. Five chromosome-level assemblies show a stable 18-chromosome karyotype, with major rearrangements creating 25 chromosomes in social parasites. Differential transposable element activity drives changes in genome sizes, with putative domestications of repetitive sequences influencing gene coding and regulatory potential. Dynamically evolving gene families and signatures of positive selection point to genus-wide variation in processes linked to foraging, diet and metabolism, immunity and detoxification, as well as adaptations for life at high altitudes. Our study reveals how bumblebee genes and genomes have evolved across the Bombus phylogeny and identifies variations potentially linked to key ecological and behavioral traits of these important pollinators.en
dc.description.versionPublished versionen
dc.format.extentPages 486-501en
dc.format.extent16 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/molbev/msaa240en
dc.identifier.eissn1537-1719en
dc.identifier.issn0737-4038en
dc.identifier.issue2en
dc.identifier.orcidSharakhov, Igor [0000-0003-0752-3747]en
dc.identifier.other5908523 (PII)en
dc.identifier.pmid32946576 (pubmed)en
dc.identifier.urihttp://hdl.handle.net/10919/104583en
dc.identifier.volume38en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000637318600013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectEvolutionary Biologyen
dc.subjectGenetics & Heredityen
dc.subjectBombusen
dc.subjectinsect diversityen
dc.subjectgenome assemblyen
dc.subjectgenome evolutionen
dc.subjectgene family evolutionen
dc.subject0601 Biochemistry and Cell Biologyen
dc.subject0603 Evolutionary Biologyen
dc.subject0604 Geneticsen
dc.subject.meshAnimalsen
dc.subject.meshBeesen
dc.subject.meshDNA Transposable Elementsen
dc.subject.meshDieten
dc.subject.meshFeeding Behavioren
dc.subject.meshAdaptation, Biologicalen
dc.subject.meshGene Componentsen
dc.subject.meshGenome, Insecten
dc.subject.meshSelection, Geneticen
dc.subject.meshBiological Evolutionen
dc.subject.meshGenome Sizeen
dc.subject.meshCodon Usageen
dc.titleGenus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traitsen
dc.title.serialMolecular Biology and Evolutionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomologyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten

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