Branched Peptide Boronic Acids (BPBAs): A Novel Mode of Binding Towards RNA
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TR Number
Date
2013-02-07
Journal Title
Journal ISSN
Volume Title
Publisher
The Royal Society of Chemistry
Abstract
We report branched peptideboronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.
Description
Keywords
HIV, AIDS, RNA, Boronic acid moieties, Branched peptide boronic acids (BPBAs)
Citation
Zhang, W., Bryson, D. I., Crumpton, J. B., Wynn, J., & Santos, W. L. (2013). Branched peptideboronic acids (BPBAs): a novel mode of binding towards RNA. Chemical Communications, 49(24), 2436-2438. doi: 10.1039/C3CC00243H