Developmental programming in response to intrauterine growth restriction impairs myoblast function and skeletal muscle metabolism.

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dc.contributor.authorYates, Dustin T.en
dc.contributor.authorMacko, Antoni R.en
dc.contributor.authorNearing, Marieen
dc.contributor.authorChen, Xiaochuanen
dc.contributor.authorRhoads, Robert P.en
dc.contributor.authorLimesand, Sean W.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2017-01-12T20:54:37Zen
dc.date.available2017-01-12T20:54:37Zen
dc.date.issued2012en
dc.description.abstractFetal adaptations to placental insufficiency alter postnatal metabolic homeostasis in skeletal muscle by reducing glucose oxidation rates, impairing insulin action, and lowering the proportion of oxidative fibers. In animal models of intrauterine growth restriction (IUGR), skeletal muscle fibers have less myonuclei at birth. This means that myoblasts, the sole source for myonuclei accumulation in fibers, are compromised. Fetal hypoglycemia and hypoxemia are complications that result from placental insufficiency. Hypoxemia elevates circulating catecholamines, and chronic hypercatecholaminemia has been shown to reduce fetal muscle development and growth. We have found evidence for adaptations in adrenergic receptor expression profiles in myoblasts and skeletal muscle of IUGR sheep fetuses with placental insufficiency. The relationship of β-adrenergic receptors shifts in IUGR fetuses because Adrβ2 expression levels decline and Adrβ1 expression levels are unaffected in myofibers and increased in myoblasts. This adaptive response would suppress insulin signaling, myoblast incorporation, fiber hypertrophy, and glucose oxidation. Furthermore, this β-adrenergic receptor expression profile persists for at least the first month in IUGR lambs and lowers their fatty acid mobilization. Developmental programming of skeletal muscle adrenergic receptors partially explains metabolic and endocrine differences in IUGR offspring, and the impact on metabolism may result in differential nutrient utilization.en
dc.description.versionPublished versionen
dc.format.extent631038 - ? page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationD. T. Yates, A. R. Macko, M. Nearing, X. Chen, R. P. Rhoads, and S. W. Limesand, “Developmental Programming in Response to Intrauterine Growth Restriction Impairs Myoblast Function and Skeletal Muscle Metabolism,” Journal of Pregnancy, vol. 2012, Article ID 631038, 10 pages, 2012. doi:10.1155/2012/631038en
dc.identifier.doihttps://doi.org/10.1155/2012/631038en
dc.identifier.eissn2090-2735en
dc.identifier.urihttp://hdl.handle.net/10919/74293en
dc.identifier.volume2012en
dc.language.isoenen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/22900186en
dc.rightsCreative Commons Attribution 3.0 Unporteden
dc.rights.holderCopyright © 2012 D. T. Yates et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectAdaptation, Physiologicalen
dc.subjectBiomarkersen
dc.subjectCatecholaminesen
dc.subjectFemaleen
dc.subjectFetal Developmenten
dc.subjectFetal Growth Retardationen
dc.subjectFetal Hypoxiaen
dc.subjectHumansen
dc.subjectHypoglycemiaen
dc.subjectMuscle Developmenten
dc.subjectMuscle, Skeletalen
dc.subjectMyoblasts, Skeletalen
dc.subjectPlacental Insufficiencyen
dc.subjectPregnancyen
dc.subjectPrenatal Exposure Delayed Effectsen
dc.titleDevelopmental programming in response to intrauterine growth restriction impairs myoblast function and skeletal muscle metabolism.en
dc.title.serialJournal of Pregnancyen
dc.typeArticle - Refereeden
dc.typeReviewen
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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