Studies on water-soluble taxol derivatives

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dc.contributor.authorZhao, Zhiyangen
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:50:35Zen
dc.date.adate2009-11-24en
dc.date.available2014-03-14T21:50:35Zen
dc.date.issued1991en
dc.date.rdate2009-11-24en
dc.date.sdate2009-11-24en
dc.description.abstractThe importance of taxol as an anticancer drug lies not only in its activity in antitumor assays but also in its unique mechanism of action. Unfortunately, taxol is not water-soluble and therefore must be given in conjunction with emulsifying agents. Modifications of taxol were carried out in order to prepare water-soluble taxol derivatives. The C-2’ hydroxyl group of taxol was substituted with various groups to increase water solubility. The synthesized taxol derivatives, 2’-((3-sulfo-1-oxopropyl)oxy)taxol sodium salt, 2’-((4-((2-sulfoethyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt, and 2’-((4-((3-sulfopropyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt were more water-soluble than taxol. The synthetic pathways to these compounds are compared and discussed.en
dc.description.degreeMaster of Scienceen
dc.format.extentviii, 67 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-11242009-020141en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-11242009-020141/en
dc.identifier.urihttp://hdl.handle.net/10919/46002en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1991.Z436.pdfen
dc.relation.isformatofOCLC# 24346600en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1991.Z436en
dc.subject.lcshPaclitaxel -- Researchen
dc.titleStudies on water-soluble taxol derivativesen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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